A fast, comprehensive screening method for doping agents in urine by gas chromatography–triple quadrupole mass spectrometry

• Published in: Journal of Chromatography A Vol. 1218; no. 21; pp. 3306 - 3316
• Main Authors: Van Eenoo, Peter, Van Gansbeke, Wim, De Brabanter, Nik, Deventer, Koen, Delbeke, Frans T.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 27.05.2011; Elsevier
• Subjects: Albuterol - urine; Anabolic steroids; Analysis; beta-adrenergic antagonists; Beta-agonist; Beta-blocker; Biological and medical sciences; Cannabis; Doping; Doping in Sports; Dronabinol - analogs & derivatives; Dronabinol - urine; Drug addictions; Estranes - urine; gas chromatography; Gas Chromatography-Mass Spectrometry - methods; General pharmacology; hormone antagonists; Humans; hydrogen; Least-Squares Analysis; liquid chromatography; mass spectrometry; Medical sciences; Narcotic; narcotics; Performance-Enhancing Substances - urine; Pharmacology. Drug treatments; Reproducibility of Results; screening; sports; steroids; Stimulant; Substance Abuse Detection - methods; Toxicology; Urine; Urine; Stimulant; Cannabis; Narcotic; Doping; Beta-blocker; Anabolic steroids; Beta-agonist; Steroid; Biological fluid; Tandem mass spectrometry; Chemical analysis; Metabolite; Volunteer; Banned substance; β-Adrenergic receptor agonist; Narcotic analgesic; Cannabinoid; Derivatization; Quadrupole spectrometer; β-Adrenergic receptor; Qualitative analysis; Drug of abuse; Antagonist; Quantitative analysis; Human; Validation; Terpenoid; Healthy subject; Coupled method; Elimination; Medical screening; Gas chromatography; Anabolic agent; Beta blocking agent

The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromat...