A fast, comprehensive screening method for doping agents in urine by gas chromatography–triple quadrupole mass spectrometry
The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromat...
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| Published in | Journal of Chromatography A Vol. 1218; no. 21; pp. 3306 - 3316 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
27.05.2011
Elsevier |
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| Online Access | Get full text |
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| Abstract | The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromatography tandem mass spectrometric method for the detection of a wide range of doping agents is described. The method can determine 13 endogenous steroids (the steroid profile), 19-norandrosterone, salbutamol and 11-nor-Δ9-tetrahydrocannabinol.9carboxylic acid in the applicable ranges and to detect qualitatively over 140 substances in accordance with the minimum required performance levels of the World Anti-Doping Agency in 1
ml of urine. The classes of substances included in the method are anabolic steroids, β2-agonists, stimulants, narcotics, hormone antagonists and modulators and beta-blockers. Moreover, using a short capillary column and hydrogen as a carrier gas the run time of the method is less than 8
min. |
|---|---|
| AbstractList | The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromatography tandem mass spectrometric method for the detection of a wide range of doping agents is described. The method can determine 13 endogenous steroids (the steroid profile), 19-norandrosterone, salbutamol and 11-nor-Δ9-tetrahydrocannabinol.9carboxylic acid in the applicable ranges and to detect qualitatively over 140 substances in accordance with the minimum required performance levels of the World Anti-Doping Agency in 1ml of urine. The classes of substances included in the method are anabolic steroids, β2-agonists, stimulants, narcotics, hormone antagonists and modulators and beta-blockers. Moreover, using a short capillary column and hydrogen as a carrier gas the run time of the method is less than 8min. The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromatography tandem mass spectrometric method for the detection of a wide range of doping agents is described. The method can determine 13 endogenous steroids (the steroid profile), 19-norandrosterone, salbutamol and 11-nor- Delta 9-tetrahydrocannabinol.9carboxylic acid in the applicable ranges and to detect qualitatively over 140 substances in accordance with the minimum required performance levels of the World Anti-Doping Agency in 1 ml of urine. The classes of substances included in the method are anabolic steroids, beta 2-agonists, stimulants, narcotics, hormone antagonists and modulators and beta-blockers. Moreover, using a short capillary column and hydrogen as a carrier gas the run time of the method is less than 8 min. The use of performance enhancing drugs in sports is prohibited. For the detection of misuse of such substances gas chromatography or liquid chromatography coupled to mass spectrometry are the most frequently used detection techniques. In this work the development and validation of a fast gas chromatography tandem mass spectrometric method for the detection of a wide range of doping agents is described. The method can determine 13 endogenous steroids (the steroid profile), 19-norandrosterone, salbutamol and 11-nor-Δ9-tetrahydrocannabinol.9carboxylic acid in the applicable ranges and to detect qualitatively over 140 substances in accordance with the minimum required performance levels of the World Anti-Doping Agency in 1 ml of urine. The classes of substances included in the method are anabolic steroids, β2-agonists, stimulants, narcotics, hormone antagonists and modulators and beta-blockers. Moreover, using a short capillary column and hydrogen as a carrier gas the run time of the method is less than 8 min. |
| Author | De Brabanter, Nik Van Eenoo, Peter Delbeke, Frans T. Deventer, Koen Van Gansbeke, Wim |
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| Keywords | Urine Stimulant Cannabis Narcotic Doping Beta-blocker Anabolic steroids Beta-agonist Steroid Biological fluid Tandem mass spectrometry Chemical analysis Metabolite Volunteer Banned substance β-Adrenergic receptor agonist Narcotic analgesic Cannabinoid Derivatization Quadrupole spectrometer β-Adrenergic receptor Qualitative analysis Drug of abuse Antagonist Quantitative analysis Human Validation Terpenoid Healthy subject Coupled method Elimination Medical screening Gas chromatography Anabolic agent Beta blocking agent |
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| SubjectTerms | Albuterol - urine Anabolic steroids Analysis beta-adrenergic antagonists Beta-agonist Beta-blocker Biological and medical sciences Cannabis Doping Doping in Sports Dronabinol - analogs & derivatives Dronabinol - urine Drug addictions Estranes - urine gas chromatography Gas Chromatography-Mass Spectrometry - methods General pharmacology hormone antagonists Humans hydrogen Least-Squares Analysis liquid chromatography mass spectrometry Medical sciences Narcotic narcotics Performance-Enhancing Substances - urine Pharmacology. Drug treatments Reproducibility of Results screening sports steroids Stimulant Substance Abuse Detection - methods Toxicology Urine |
| Title | A fast, comprehensive screening method for doping agents in urine by gas chromatography–triple quadrupole mass spectrometry |
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