Mechanochemical Preparation, Solid-State Characterization, and Antimicrobial Performance of Copper and Silver Nitrate Coordination Polymers with L- and DL-Arginine and Histidine

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5180
• Main Authors: Fiore, Cecilia, Lekhan, Andrii, Bordignon, Simone, Chierotti, Michele R, Gobetto, Roberto, Grepioni, Fabrizia, Turner, Raymond J, Braga, Dario
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Amino acids; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; antimicrobials; Arginine; Arginine - pharmacology; Bacteria; Cell division; Chirality; co-crystallization; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Coordination polymers; copper; Copper - chemistry; Copper - pharmacology; crystal engineering; Crystallography, X-Ray; Diffraction; Drug resistance; Drug resistance in microorganisms; Escherichia coli; Histidine; Ligands; Lysogeny; Magnetic resonance spectroscopy; Medical equipment; Metals; Nitrates; NMR; NMR spectroscopy; Nuclear magnetic resonance; Polymer industry; Polymers; Polymers - chemistry; Polymers - pharmacology; Salts; Silver; Silver compounds; Silver nitrate; Silver Nitrate - pharmacology; Single crystals; Slurries; Solid state; Spectrum analysis; United Kingdom; Massachusetts; coordination polymers; co-crystallization; mechanochemistry; amino acids; copper; silver; antimicrobials; crystal engineering
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24065180

The antimicrobial activity of the novel coordination polymers obtained by co-crystallizing the amino acids arginine or histidine, as both enantiopure L and racemic DL forms, with the salts Cu(NO ) and AgNO has been investigated to explore the effect of chirality in the cases of enantiopure and racemic forms. The compounds [Cu·AA·(NO ) ] and [Ag·AA·NO ] (AA = L-Arg, DL-Arg, L-His, DL-His) were prepared by mechanochemical, slurry, and solution methods and characterized by X-ray single-crystal and powder diffraction in the cases of the copper coordination polymers, and by powder diffraction and by solid-state NMR spectroscopy in the cases of the silver compounds. The two pairs of coordination polymers, [Cu·L-Arg·(NO ) ·H O] and [Cu·DL-Arg·(NO ) ·H O] , and [Cu·L-Hys·(NO ) ·H O] and [Cu·DL-His·(NO ) ·H O] , have been shown to be isostructural in spite of the different chirality of the amino acid ligands. A similar structural analogy could be established for the silver complexes on the basis of SSNMR. The activity against the bacterial pathogens , , and was assessed by carrying out disk diffusion assays on lysogeny agar media showing that, while there is no significant effect arising from the use of enantiopure or chiral amino acids, the coordination polymers exert an appreciable antimicrobial activity comparable, when not superior, to that of the metal salts alone.