The ins and outs of bacterial iron metabolism

Summary Iron is a critical nutrient for the growth and survival of most bacterial species. Accordingly, much attention has been paid to the mechanisms by which host organisms sequester iron from invading bacteria and how bacteria acquire iron from their environment. However, under oxidative stress c...

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Bibliographic Details
Published inMolecular microbiology Vol. 93; no. 4; pp. 609 - 616
Main Authors Frawley, Elaine R., Fang, Ferric C.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.08.2014
Subjects
Animals
Bacteria
Bacteriology
Biochemistry
Homeostasis
Host-Pathogen Interactions
Humans
Iron
Iron - metabolism
Salmonella
Salmonella enterica
Salmonella Infections - immunology
Salmonella Infections - metabolism
Salmonella Infections - microbiology
Salmonella typhimurium - metabolism
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Summary:Summary Iron is a critical nutrient for the growth and survival of most bacterial species. Accordingly, much attention has been paid to the mechanisms by which host organisms sequester iron from invading bacteria and how bacteria acquire iron from their environment. However, under oxidative stress conditions such as those encountered within phagocytic cells during the host immune response, iron is released from proteins and can act as a catalyst for Fenton chemistry to produce cytotoxic reactive oxygen species. The transitory efflux of free intracellular iron may be beneficial to bacteria under such conditions. The recent discovery of putative iron efflux transporters in Salmonella enterica serovar Typhimurium is discussed in the context of cellular iron homeostasis.
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ISSN:0950-382X
1365-2958
DOI:10.1111/mmi.12709