Visible-Light-Induced Decarboxylative Functionalization of Carboxylic Acids and Their Derivatives

• Published in: Angewandte Chemie International Edition Vol. 54; no. 52; pp. 15632 - 15641
• Main Authors: Xuan, Jun, Zhang, Zhao-Guo, Xiao, Wen-Jing
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 21.12.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Acids; Carboxylic acids; Catalysis; Chemical reactions; Cross coupling; CC coupling; Decarboxylation; photochemistry; Photoredox catalysis; radicals; Substrates; synthetic methods; radicals; photochemistry; synthetic methods; carboxylic acids; CC coupling
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201505731

Visible‐light‐induced radical decarboxylative functionalization of carboxylic acids and their derivatives has recently received considerable attention as a novel and efficient method to create CC and CX bonds. Generally, this visible‐light‐promoted decarboxylation process can smoothly occur under mild reaction conditions with a broad range of substrates and an excellent functional‐group tolerance. The radical species formed from the decarboxylation step can participate in not only single photocatalytic transformations, but also dual‐catalytic cross‐coupling reactions by combining photoredox catalysis with other catalytic processes. Recent advances in this research area are discussed herein. Photo op: A novel functionalization reaction using visible‐light‐induced photoredox catalysis has recently been developed (see title). The formed radical species can participate in not only single photocatalytic transformations, but also dual‐catalytic reactions by combining photoredox catalysis with other catalytic methods. Recent advances in this research area are discussed herein.