A case series of platelet rich plasma in chronic venous ulcers

• Published in: Regenerative therapy Vol. 18; pp. 51 - 58
• Main Authors: Huber, Stephany Cares, de Moraes Martinelli, Beatriz, Quintero, Melissa, de Paula, Lais Ívina Silva, Cataldo, Jose Luiz, de Lima Montalvão, Silmara Aparecida, Annichino-Bizzacchi, Joyce M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Chronic venous ulcer; Healing; Original; Platelet rich plasma; Wounds; Platelet rich plasma; Wounds; Healing; Chronic venous ulcer
• ISSN: 2352-3204; 2352-3204
• DOI: 10.1016/j.reth.2021.03.005

Venous ulcers are the most common type of leg wounds (80%) and the main cause is chronic venous insufficiency. Autologous platelet-rich plasma (PRP) is a potential wound healing treatment due to its great variety of growth factors. The aim of this study was to describe in a case series the results of poor-leukocyte PRP (P-PRP) or saline for the treatment of chronic non-healing ulcers of the lower extremity. Eight patients were treated according to the topical therapy: saline solution or P-PRP gel. All patients used double compression stocks and were assisted by a vascular practitioner for up to 12 months or until wound healing. The treatment was performed weekly with cleaning of the affected area, macroscopic evaluation (area measurement and photos) and P-PRP or saline application, and closure with Tegaderm®. Trial Registration: Retrospectively approved by Brazilian Clinical Trials, register number RBR-7zhgb3 (http://www.ensaiosclinicos.gov.br/rg/RBR-7zhgb3/). All patients showed signs of wound healing with a reduction in wound size and ulcer numbers, but more evident with P-PRP application. The results suggested that P-PRP presented a better result when compared to saline solution in the healing process of long clinical course chronic venous ulcers, when associated to compressive stocks and topical care.