Prefrontal–hippocampal pathways underlying inhibitory control over memory

• Published in: Neurobiology of learning and memory Vol. 134; no. Pt A; pp. 145 - 161
• Main Authors: Anderson, Michael C., Bunce, Jamie G., Barbas, Helen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016; Elsevier BV
• Subjects: Anterior cingulate; Forgetting; Gyrus Cinguli - physiology; Hippocampus; Hippocampus - physiology; Humans; Inhibition, Psychological; Inhibitory control; Memory; Mental Recall - physiology; Neurobiology; Nucleus reuniens; Prefrontal Cortex - physiology; Primates; Retrieval suppression; Thinking - physiology; Forgetting; Retrieval suppression; Anterior cingulate; Inhibitory control; Nucleus reuniens; Hippocampus
• ISSN: 1074-7427; 1095-9564; 1095-9564
• DOI: 10.1016/j.nlm.2015.11.008

•Retrieval suppression is a model for understanding inhibitory control over thought.•Suppression engages dorsolateral prefrontal cortex (DLPFC), reducing hippocampal activity.•Anterior cingulate cortex (ACC) may mediate DLPFC’s influence on the hippocampus.•ACC pathways may gate entorhinal input to the hippocampus to prevent retrieval.•ACC may suppress hippocampal activity via nucleus reuniens, to stop retrieval. A key function of the prefrontal cortex is to support inhibitory control over behavior. It is widely believed that this function extends to stopping cognitive processes as well. Consistent with this, mounting evidence establishes the role of the right lateral prefrontal cortex in a clear case of cognitive control: retrieval suppression. Retrieval suppression refers to the ability to intentionally stop the retrieval process that arises when a reminder to a memory appears. Functional imaging data indicate that retrieval suppression involves top-down modulation of hippocampal activity by the dorsolateral prefrontal cortex, but the anatomical pathways supporting this inhibitory modulation remain unclear. Here we bridge this gap by integrating key findings about retrieval suppression observed through functional imaging with a detailed consideration of relevant anatomical pathways observed in non-human primates. Focusing selectively on the potential role of the anterior cingulate cortex, we develop two hypotheses about the pathways mediating interactions between lateral prefrontal cortex and the medial temporal lobes during suppression, and their cellular targets: the entorhinal gating hypothesis, and thalamo-hippocampal modulation via the nucleus reuniens. We hypothesize that whereas entorhinal gating is well situated to stop retrieval proactively, thalamo-hippocampal modulation may interrupt an ongoing act of retrieval reactively. Isolating the pathways that underlie retrieval suppression holds the potential to advance our understanding of a range of psychiatric disorders characterized by persistent intrusive thoughts. More broadly, an anatomical account of retrieval suppression would provide a key model system for understanding inhibitory control over cognition.