Rational Vaccine Design in the Time of COVID-19

As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design." We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses includin...

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Bibliographic Details
Published inCell Host & Microbe Vol. 27; no. 5; pp. 695 - 698
Main Authors Burton, Dennis R, Walker, Laura M
Format Journal Article Web Resource
LanguageEnglish
Published United States Elsevier BV 13.05.2020
Elsevier Inc
Subjects
AIDS Vaccines - immunology
AIDS Vaccines - standards
Antibodies, Viral - immunology
Antigens, Viral - immunology
Betacoronavirus - immunology
Coronavirus Infections - immunology
Coronavirus Infections - prevention & control
COVID-19
COVID-19 Vaccines
Forum
Humans
Influenza Vaccines - immunology
Influenza Vaccines - standards
Pandemics - prevention & control
Pneumonia, Viral - immunology
Pneumonia, Viral - prevention & control
Research Design - trends
SARS-CoV-2
Viral Vaccines - immunology
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Summary:As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design." We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses including HIV and influenza, as well as coronaviruses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2020.04.022