Role of intestinal flora in colorectal cancer from the metabolite perspective: a systematic review

• Published in: Cancer management and research Vol. 10; pp. 199 - 206
• Main Authors: Han, Shuwen, Gao, Jianlan, Zhou, Qing, Liu, Shanshan, Wen, Caixia, Yang, Xi
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Adenosine triphosphate; Amino acids; Anopheles; Antigens; Bacteria; Cancer research; Carbohydrate metabolism; Carbohydrates; Care and treatment; Colorectal cancer; Deoxyribonucleic acid; DNA; E coli; Ecosystems; Flora; Genetic aspects; Hospitals; Inflammation; Lipid metabolism; Lipids; Listeria; Metabolism; Metabolites; Microbiology; Microbiota (Symbiotic organisms); Patient outcomes; Plants (Organisms); Review; Salmonella; Subject heading schemes; Systematic review; Tumorigenesis; Tumors; colorectal cancer; bacteria; carbohydrate metabolism; inflammation; amino acids; lipid metabolism; microbiology
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S153482

Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. In total, 57 articles were included after identification and screening. The pertinent literature on floral metabolites in colorectal cancer from three metabolic perspectives - including carbohydrate, lipid, and amino acid metabolism - was analyzed. An association network regarding the role of intestinal flora from a metabolic perspective was constructed by analyzing the previous literature to provide direction and insight for further research on intestinal flora in colorectal cancer.