Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from...

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Bibliographic Details
Published inJournal of computational physics Vol. 244; pp. 22 - 40
Main Authors Xiao, Nan, Humphrey, Jay D., Figueroa, C. Alberto
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2013
Subjects
Arterial stiffening
ARTERIES
BLOOD FLOW
BOUNDARY CONDITIONS
Computation
Computer simulation
COMPUTERIZED TOMOGRAPHY
Fluid–structure interaction
Formability
Full-body arterial model
Hemodynamics
HYPERTENSION
MATHEMATICAL METHODS AND COMPUTING
Mathematical models
Multiscale modeling
Networks
PATIENTS
Pulse wave velocity
SIMULATION
Three dimensional models
THREE-DIMENSIONAL CALCULATIONS
VELOCITY
WAVE FORMS
WAVE PROPAGATION
Hypertension
Fluid–structure interaction
Wave propagation
Pulse wave velocity
Full-body arterial model
Hemodynamics
Arterial stiffening
Multiscale modeling
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Summary:In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.
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ISSN:0021-9991
1090-2716
DOI:10.1016/j.jcp.2012.09.016