Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications

Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process, is predominantly associated with low back pain and permanent disability. Pyroptosis is a type of lytic programmed cell death triggered by the activation of inflammasomes and caspases. Unlike apoptosis, pyr...

Full description

Saved in:
Bibliographic Details
Published inBiomolecules (Basel, Switzerland) Vol. 12; no. 12; p. 1804
Main Authors Luo, Jieya, Yang, Yuxuan, Wang, Xuan, Chang, Xingyu, Fu, Songbo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2022
MDPI
Subjects
Anti-inflammatory agents
Apoptosis
Care and treatment
Causes of
Cell death
Degeneration
Degeneration (Pathology)
Disease
Extracellular matrix
Health aspects
Humans
Inflammasomes
Inflammasomes - metabolism
Inflammation
Intervertebral Disc Degeneration
Intervertebral discs
Intervertebral disk
Low back pain
NLRP3 inflammasome
Nucleus pulposus
Nucleus Pulposus - metabolism
Nucleus Pulposus - pathology
Pathogenesis
Physiological aspects
Proteins
Pyrin protein
Pyroptosis
Quality of life
Review
Tumor necrosis factor-TNF
Vertebrae
China
intervertebral disc degeneration
pyroptosis
NLRP3 inflammasome
nucleus pulposus
Online AccessGet full text

Cover

More Information
Summary:Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process, is predominantly associated with low back pain and permanent disability. Pyroptosis is a type of lytic programmed cell death triggered by the activation of inflammasomes and caspases. Unlike apoptosis, pyroptosis is characterized by the rupture of the plasma membrane and the release of inflammatory mediators, accelerating the destruction of the extracellular matrix (ECM). Recent studies have shown that pyrin domain-containing 3 (NLRP3) inflammasome-mediated pyroptosis in nucleus pulposus (NP) cells is activated in the progression of IDD. Furthermore, targeting pyroptosis in IDD demonstrates the excellent capacity of ECM remodeling and its anti-inflammatory properties, suggesting that pyroptosis is involved in the IDD process. In this review, we briefly summarize the molecular mechanism of pyroptosis and the pathogenesis of IDD. We also focus on the role of pyroptosis in the pathological progress of IDD and its targeted therapeutic application.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12121804