Targeting the Wnt/β-catenin signaling pathway in cancer

• Published in: Journal of hematology and oncology Vol. 13; no. 1; p. 165
• Main Authors: Zhang, Ya, Wang, Xin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 04.12.2020; BMC
• Subjects: Antagonists; Antibodies; Breast cancer; Cancer; Cancer stem cell; Cancer therapies; Cell differentiation; Cell growth; Cell proliferation; Clinical trials; Hematology; Kinases; Ligands; Oncology; Ovarian cancer; Pancreatic cancer; Phosphorylation; Physiology; Proteins; Review; Signal transduction; Stem cells; Targeted therapy; Transcription; Tumorigenesis; Tumors; Wnt protein; Wnt/β-catenin signaling pathway; β-Catenin; Cancer stem cell; Wnt/β-catenin signaling pathway; Targeted therapy; Cancer
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-020-00990-3

The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.