The gut endocrine system as a coordinator of postprandial nutrient homoeostasis

• Published in: Proceedings of the Nutrition Society Vol. 71; no. 4; pp. 456 - 462
• Main Author: Gribble, Fiona M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.11.2012
• Subjects: 70th Anniversary Conference on ‘Body weight regulation – food, gut and brain signalling’; Animal models; Animals; appetite; bariatric surgery; Biological and medical sciences; blood flow; cholecystokinin; Cholecystokinin - metabolism; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Eating - physiology; Endocrine system; Enteroendocrine Cells - metabolism; epithelium; Feeding. Feeding behavior; Food; Fundamental and applied biological sciences. Psychology; gastric inhibitory polypeptide; Gastrointestinal surgery; gastrointestinal system; Gastrointestinal Tract - metabolism; Glucagon; glucagon-like peptide 1; Glucagon-Like Peptide 1 - metabolism; Glucose; Heart surgery; Homeostasis; Hormones; Humans; in vitro studies; Ingestion; Large intestine; Nutrients; Obesity - metabolism; Obesity - surgery; physiological response; Physiological responses; Physiology; Polypeptides; Postprandial Period; receptors; Receptors, Gastrointestinal Hormone - metabolism; secretion; Signal Transduction; Small intestine; Symposium I: Food–gut interactions; transporters; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Enteroendocrine; Obesity; Glucagon-like peptide-1; Glucose-dependent insulinotropic polypeptide; Cholecystokinin; Diabetes; Endocrinopathy; Digestive system; Postprandial; Diabetes mellitus; Nutrition disorder; Gut; Glucose; Neuropeptide; Glucagon like peptide 1; Vertebrata; Gastrointestinal hormone; Mammalia; Polypeptide; Nutrient; Nutritional status
• ISSN: 0029-6651; 1475-2719; 1475-2719
• DOI: 10.1017/S0029665112000705

Hormones from the gastrointestinal (GI) tract are released following food ingestion and trigger a range of physiological responses including the coordination of appetite and glucose homoeostasis. The aim of this review is to discuss the pathways by which food ingestion triggers secretion of cholecystokinin (CCK), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and the altered patterns of gut hormone release observed following gastric bypass surgery. Our understanding of how ingested nutrients trigger secretion of these gut hormones has increased dramatically, as a result of physiological studies in human subjects and animal models and in vitro studies on cell lines and primary intestinal cultures. Specialised enteroendocrine cells located within the gut epithelium are capable of directly detecting a range of nutrient stimuli through a range of receptors and transporters. It is concluded that the arrival of nutrients at the apical surface of enteroendocrine cells is a major stimulus for gut hormone release, thereby coupling these endocrine signals to the arrival of absorbed nutrients in the bloodstream.