Synthesis of New Zirconium Magnetic Nanocomposite as a Bioactive Agent and Green Catalyst in the Four-Component Synthesis of a Novel Multi-Ring Compound Containing Pyrazole Derivatives

• Published in: Nanomaterials (Basel, Switzerland) Vol. 12; no. 24; p. 4468
• Main Authors: Asiri, Mohammed, Abdulsalam, Ahmed Ghalib, Kahtan, Mustafa, Alsaikhan, Fahad, Farhan, Issa, Mutlak, Dhameer A, Hadrawi, Salema K, Suliman, Muath, Di Lorenzo, Ritamaria, Laneri, Sonia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: antibacterial activity; Antifungal agents; Antimicrobial agents; bioactive agent; Biological properties; Cancer; Catalysts; Chemical synthesis; Cyclic compounds; Diffraction patterns; Electron microscopy; Ethanol; four-component reaction; Fourier transforms; Fungicides; green catalyst; Green chemistry; Heterocyclic compounds; Infrared imagery; Infrared spectroscopy; Irradiation; Ligands; Magnetic properties; Magnetometers; Microwave radiation; Microwaves; Morphology; Nanocomposites; Nanoparticles; Nitrogen; Pyrazole; pyrazole derivatives; Pyrazoles; Raw materials; Scanning electron microscopy; Sulfur compounds; Transmission electron microscopy; X-ray diffraction; Zirconium; zirconium magnetic nanocomposite; Iraq; United States > US; Netherlands; antibacterial activity; bioactive agent; pyrazole derivatives; green catalyst; four-component reaction; zirconium magnetic nanocomposite; antifungal activity
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano12244468

New nanocomposites containing zirconium were synthesized using microwave irradiation. Their structure was confirmed by vibrating sample magnetometer (VSM) curves, X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) and transmission electron microscopy (TEM) images, Fourier transform infrared spectroscopy (FT-IR), and Brunauer-Emmett-Teller (BET) N adsorption/desorption isotherms. After the structure confirmation of the zirconium magnetic nanocomposite, the catalytic properties in the synthesis of pyrazole derivatives were investigated. Next, the biological activities of the zirconium magnetic nanocomposite, such as the antibacterial and antifungal activities, were investigated. The research results showed that the zirconium magnetic nanocomposite has high catalytic properties and can be used as a magnetic nanocatalyst for synthesizing heterocyclic compounds such as pyrazole derivatives in addition to having high biological properties. The unique properties of the nanoparticles can be attributed to their synthesis method and microwave radiation.