3-Mercaptopropionic acid as a new reagent for the industrially applicable synthesis of highly pure O-desmethylvenlafaxine from venlafaxine

3-Mercaptopropionic acid was introduced as a cheap new O-demethylating agent as exemplified by its application in the synthesis of antidepressant O-desmethylvenlafaxine from venlafaxine. The application of 3-mercaptopropionic acid allowed high conversion of venlafaxine to O-desmethylvenlafaxine and...

Full description

Saved in:
Bibliographic Details
Published inJournal of sulfur chemistry Vol. 36; no. 1; pp. 67 - 73
Main Authors Furlan, Borut, Časar, Zdenko, Šterk, Damjan, Fabris, Jan
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 02.01.2015
Taylor & Francis Ltd
Subjects
Acids
aryl alkyl ethers
demethylation
drugs
mercapto alkyl carboxylic acid
O-desmethylvenlafaxine
Online AccessGet full text

Cover

More Information
Summary:3-Mercaptopropionic acid was introduced as a cheap new O-demethylating agent as exemplified by its application in the synthesis of antidepressant O-desmethylvenlafaxine from venlafaxine. The application of 3-mercaptopropionic acid allowed high conversion of venlafaxine to O-desmethylvenlafaxine and a facile workup, which enabled the isolation of the desired O-desmethylvenlafaxine with a high >99.8% chromatographic purity and 76% yield by a simple extractive workup followed by the precipitation.
ISSN:1741-5993
1741-6000
DOI:10.1080/17415993.2014.964241