Increased Antimicrobial Resistance among Sputum Pathogens from Patients with Hyperglycemia

• Published in: Infection and drug resistance Vol. 13; pp. 1723 - 1733
• Main Authors: Yi, Huahua, Huang, Jingwen, Guo, Lingxi, Zhang, Qiurui, Qu, Jieming, Zhou, Min
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Dove; Dove Medical Press
• Subjects: antimicrobial resistance; Bacteria; diabetes; Glucose; Health aspects; Hospital patients; Hyperglycemia; Imipenem; k. pneumoniae; Medical schools; Meropenem; Methicillin; Microbial drug resistance; Original Research; Pneumonia; s. aureus; Staphylococcus aureus; Sulbactam; Tigecycline; China; K. pneumoniae; hyperglycemia; S. aureus; antimicrobial resistance; diabetes
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S243732

Glucose management is of great significance. Infection and hyperglycemia are a vicious circle. This study was conducted to describe distribution and antimicrobial resistance of bacteria isolated from patients with normoglycemia, hyperglycemia, or diabetes on admission. A retrospective study was conducted in a teaching hospital from January 2015 to March 2017. Bacteria were identified by the Vitek 2 automated system and antimicrobial susceptibility determined. A total of 1,163 patients were included: 582 with normoglycemia, 292 with hyperglycemia and 289 with diabetes. , , , , , and were the main species isolated from these patients, with 1,616 unduplicated isolates from sputum samples. Patients with hyperglycemia were more prone to carry more than one species, and the rate of multidrug-resistant and methicillin-resistant was higher in this group. from hyperglycemia patients demonstrated increased resistance to carbapenems, especially imipenem ( =0.002) and meropenem ( =0.003), than those isolated from patients with normoglycemia or diabetes. No significance was detected for , , or between nondiabetes and diabetes patients. In addition, hyperglycemia patients had a higher rate of ICU admission ( 0.035) and a lower survival rate ( <0.001). Patients with hyperglycemia were more prone to carry bacteria, especially multidrug-resistant and methicillin-resistant . Assessing glucose on admission is of great significance in predicting bacterial carriage and antimicrobial resistance.