Aorta Calcification Increases the Risk of Anastomotic Leakage After Gastrectomy in Gastric Cancer Patients

• Published in: Cancer management and research Vol. 13; pp. 3857 - 3865
• Main Authors: Tao, Wei, Cheng, Yu-Xi, Zou, Ying-Ying, Peng, Dong, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Abdomen; Body mass index; Calcification; Cancer; Cancer patients; Cardiovascular disease; Care and treatment; Chronic obstructive pulmonary disease; Coronary vessels; Diabetes; gastrectomy; Gastric cancer; Gastrointestinal surgery; Hospitals; Hypertension; leakage; Length of stay; Lymphatic system; Medical records; Mortality; Multivariate analysis; Oncology, Experimental; Original Research; Patients; Quality of life; Regression analysis; Risk factors; Stomach cancer; Tomography; China; calcification; gastrectomy; gastric cancer; leakage
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S306942

The purpose of the present study was to evaluate whether vascular calcification is a risk factor for anastomotic leakage after gastrectomy in gastric cancer patients. Patients with confirmed gastric cancer were collected from the database of a single clinical center from January 2013 to January 2019. The calcification score and anastomotic leakage were recorded, and predictors of anastomotic leakage were analyzed. A total of 856 patients were included in this study; 818 patients had no anastomotic leakage, and 38 patients had anastomotic leakage. The ratio of hypertension status (p=0.011), open gastrectomy (p=0.012), postoperative length of stay (p=0.000), aorta calcification score (p=0.000) and celiac axis calcification (p=0.000) were higher in the anastomotic leakage group than in the nonanastomotic leakage group. In multivariate analysis, aorta calcification (p=0.029, odds ratio =2.425, 95% CI=1.095-5.491) was an independent predictor of the anastomotic leakage. Aorta calcification is an independent risk factor for anastomotic leakage after gastrectomy in gastric cancer patients.