The association of CMV with NK-cell reconstitution depends on graft source: results from BMT CTN-0201 samples

•CMV reactivation was associated with the maturation of reconstituting NK cells from BM, but not PB, unrelated donor grafts.•CMV reactivation was associated with CD8+, but not CD4+, T-cell recovery, more so after BM than PB unrelated donor grafts.

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Bibliographic Details
Published inBlood advances Vol. 3; no. 16; pp. 2465 - 2469
Main Authors Rashidi, Armin, Luo, Xianghua, Cooley, Sarah, Anasetti, Claudio, Waller, Edmund K., Brunstein, Claudio G., Cichocki, Frank, Weisdorf, Daniel J., Miller, Jeffrey S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.08.2019
American Society of Hematology
Elsevier
Subjects
Adolescent
Adult
Aged
Bone Marrow Transplantation - adverse effects
Bone Marrow Transplantation - methods
Child
Child, Preschool
Cytomegalovirus Infections - etiology
Histocompatibility Testing
Humans
Immune Reconstitution
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Middle Aged
Stimulus Report
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Tissue Donors
Virus Activation - immunology
Young Adult
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Summary:•CMV reactivation was associated with the maturation of reconstituting NK cells from BM, but not PB, unrelated donor grafts.•CMV reactivation was associated with CD8+, but not CD4+, T-cell recovery, more so after BM than PB unrelated donor grafts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2019000298