HMGNs: The enhancer charmers
The DNase I hypersensitive sites (DHSs) of chromatin constitute one of the best landmarks of eukaryotic genes that are poised and/or activated for transcription. For over 35 years, the high‐mobility group nucleosome‐binding chromosomal proteins HMGN1 and HMGN2 have been shown to play a role in the e...
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Published in | BioEssays Vol. 38; no. 3; pp. 226 - 231 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Published for ICSU Press by Cambridge University Press
01.03.2016
Blackwell Publishing Ltd Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The DNase I hypersensitive sites (DHSs) of chromatin constitute one of the best landmarks of eukaryotic genes that are poised and/or activated for transcription. For over 35 years, the high‐mobility group nucleosome‐binding chromosomal proteins HMGN1 and HMGN2 have been shown to play a role in the establishment of these chromatin‐accessible domains at transcriptional regulatory elements, namely promoters and enhancers. The critical presence of HMGNs at enhancers, as highlighted by a recent publication, suggests a role for them in the structural and functional fine‐tuning of the DHSs in vertebrates. As we review here, while preferentially out‐competing histone H1 binding and invading neighbor nucleosomes, HMGNs may also modulate histone H3 at serine 10 (H3S10ph), which plays an important role in enhancer function and transcriptional initiation. |
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Bibliography: | http://dx.doi.org/10.1002/bies.201500157 ark:/67375/WNG-B1XJM061-9 ArticleID:BIES201500157 istex:CD1F391D89891E211EFE938D67DB2C0F5C67787F Canadian Institutes of Health Research (CIHR) - No. MOP-130417 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0265-9247 1521-1878 |
DOI: | 10.1002/bies.201500157 |