“Anagrelide-induced pulmonary arterial hypertension”: a rare case of drug-induced pulmonary arterial hypertension

Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts...

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Bibliographic Details
Published inPulmonary circulation Vol. 9; no. 4; pp. 1 - 3
Main Authors Sumimoto, Keiko, Taniguchi, Yu, Matsuoka, Yoichiro, Onishi, Hiroyuki, Emoto, Noriaki, Hirata, Ken-ichi
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.10.2019
John Wiley & Sons, Inc
Wiley
Subjects
anagrelide
Blood cancer
Case Report
drug‐induced pulmonary arterial hypertension
Interferon
polycythemia vera
Potassium
Pulmonary hypertension
Side effects
polycythemia vera
anagrelide
drug-induced pulmonary arterial hypertension
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Summary:Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts in patients with myeloproliferative disorders. We report the case of a 70-year-old female patient who developed pulmonary arterial hypertension after taking anagrelide for the treatment of polycythemia vera. Pulmonary arterial hypertension promptly improved after the discontinuation of anagrelide. Anagrelide-induced pulmonary arterial hypertension is a very rare disease, and our case shows that it might be reversible.
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045894019896682