Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat
Background: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success. Aims and Objectives: The present study was conducted to compare the effici...
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Published in | Journal of anaesthesiology, clinical pharmacology Vol. 32; no. 2; pp. 168 - 171 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
India
Wolters Kluwer - Medknow Publications
01.04.2016
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications |
Subjects | |
Online Access | Get full text |
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Summary: | Background: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success.
Aims and Objectives: The present study was conducted to compare the efficiency of preoperative nebulization of normal saline and magnesium sulfate in reducing the incidence of POST following GA.
Materials and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologist (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group A are nebulized with 3 ml of normal saline and the patients in Group B are nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min, 5 min before induction of anesthesia. The incidence of POST at rest and on swallowing and any undue complaints at 0, 2, 4, and 24 h in the postoperative period are evaluated.
Results: There is no significant difference in POST at rest during 0th, 2nd and 4th h between normal saline and MgSO4. Significant difference is seen at 24th h, where MgSO4lessens POST. There is no significant difference in POST "on swallowing" during 0th and 2nd h between normal saline and MgSO4. Significant difference is seen at 4th h, where MgSO4has been shown to lessen POST.
Conclusions: MgSO4significantly reduces the incidence of POST compared to normal saline. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0970-9185 2231-2730 |
DOI: | 10.4103/0970-9185.173367 |