Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

• Published in: International journal of molecular sciences Vol. 20; no. 16; p. 3926
• Main Authors: Zhao, Xing, Cai, Yujie, Xu, Jianzhen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.08.2019; MDPI
• Subjects: Adenosine; Animals; Binding sites; biogenesis; Biomarkers, Tumor; Biosynthesis; Cancer; carcinogenesis; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; circRNAs; Editing; Enzymes; Epigenetics; flanking introns; Gene expression; Gene Expression Regulation, Neoplastic; Gene regulation; Genes; Genetic Variation; Genomes; genomic alternation; Humans; Introns; Mass spectrometry; Mass spectroscopy; MicroRNAs; Neoplasms - genetics; Neoplasms - metabolism; Proteins; Review; RNA Splicing; RNA, Circular; RNA, Untranslated - genetics; RNA-binding protein; RNA-Binding Proteins - metabolism; Roles; Splicing; Stem cells; Transcription; flanking introns; circRNAs; RNA-binding protein; biogenesis; carcinogenesis; genomic alternation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20163926

CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.