Mast Cell Functions Linking Innate Sensing to Adaptive Immunity

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 12; p. 2538
• Main Authors: Katsoulis-Dimitriou, Konstantinos, Kotrba, Johanna, Voss, Martin, Dudeck, Jan, Dudeck, Anne
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.11.2020; MDPI
• Subjects: Adaptive immunity; antigen presentation; Antigen-presenting cells; Antigens; Cell activation; Chemokines; Connective tissue; Cytokines; dendritic cell; Edema; Growth factors; Histamine; Hypersensitivity; Immune response; Infections; Inflammation; Innate immunity; Lymph nodes; Lymphocytes T; mast cell; Mast cells; Neuropeptides; Neutrophils; Pathogens; Recruitment; Review; T cell; Tumor necrosis factor-TNF; mast cell; antigen presentation; T cell; adaptive immunity; dendritic cell
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells9122538

Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs not only play an important role in initiating innate immune responses, but also influence the onset, kinetics, and amplitude of the adaptive arm of immunity or fine-tune the mode of the adaptive reaction. Intriguingly, MCs have been shown to affect T-cell activation by direct interaction or indirectly, by modifying the properties of antigen-presenting cells, and can even modulate lymph node-borne adaptive responses remotely from the periphery. In this review, we provide a summary of recent findings that explain how MCs act as a link between the innate and adaptive immunity, all the way from sensing inflammatory insult to orchestrating the final outcome of the immune response.