Identification of Senescent Cells in Peri-Implantitis and Prevention of Mini-Implant Loss Using Senolytics

• Published in: International journal of molecular sciences Vol. 24; no. 3; p. 2507
• Main Authors: Yang, Niuxin, Nakagawa, Masato, Nishiura, Aki, Yamada, Masahiro, Morikuni, Hidetoshi, Honda, Yoshitomo, Matsumoto, Naoyuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.01.2023; MDPI
• Subjects: Alzheimer's disease; Animals; Bacterial infections; Bone Resorption; Cell cycle; Cellular Senescence; Chronic illnesses; Cytokines; Dasatinib; Dental Implants; Infections; Inflammation; Inflammatory diseases; mini-implant; Orthodontic Anchorage Procedures; Orthodontics; peri-implantitis; Peri-Implantitis - drug therapy; Peri-Implantitis - prevention & control; Phosphatase; Quercetin; Rats; Senescence; senolytics; Signs and symptoms; Transplants & implants; mini-implant; senescence; Dasatinib; orthodontics; Quersetin; senolytics; peri-implantitis

Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed "senolytics", can improve the symptoms of such diseas...