Identification of Senescent Cells in Peri-Implantitis and Prevention of Mini-Implant Loss Using Senolytics

Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed "senolytics", can improve the symptoms of such diseas...

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Published inInternational journal of molecular sciences Vol. 24; no. 3; p. 2507
Main Authors Yang, Niuxin, Nakagawa, Masato, Nishiura, Aki, Yamada, Masahiro, Morikuni, Hidetoshi, Honda, Yoshitomo, Matsumoto, Naoyuki
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.01.2023
MDPI
Subjects
Alzheimer's disease
Animals
Bacterial infections
Bone Resorption
Cell cycle
Cellular Senescence
Chronic illnesses
Cytokines
Dasatinib
Dental Implants
Infections
Inflammation
Inflammatory diseases
mini-implant
Orthodontic Anchorage Procedures
Orthodontics
peri-implantitis
Peri-Implantitis - drug therapy
Peri-Implantitis - prevention & control
Phosphatase
Quercetin
Rats
Senescence
senolytics
Signs and symptoms
Transplants & implants
mini-implant
senescence
Dasatinib
orthodontics
Quersetin
senolytics
peri-implantitis
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Summary:Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed "senolytics", can improve the symptoms of such diseases. However, the relationship between peri-implantitis and senescent cells remains unclear. In this study, we evaluated the presence of senescent cells in a rat peri-implantitis model developed with a gum ring. The effect on bone resorption and implant loss was also investigated with and without senolytics (Dasatinib and Quercetin). The number of senescence markers (p19, p21, and p16) was found to increase, and implant detachment occurred in 24 days. After the administration of senolytics, the number of senescence markers decreased and implant detachment was inhibited. This study suggests that senescent cells aggravate peri-implantitis and senolytic administration latently reduces implant loss by inhibiting senescence-related mechanisms.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24032507