Application of liposomes in drug development--focus on gastroenterological targets

• Published in: International Journal of Nanomedicine Vol. 8; no. 1; pp. 1325 - 1334
• Main Authors: Zhang, Jian-Xin, Wang, Kun, Mao, Zheng-Fa, Fan, Xin, Jiang, De-Li, Chen, Min, Cui, Lei, Sun, Kang, Dang, Sheng-Chun
• Format: Journal Article Book Review
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2013; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Animals; colorectal cancer; Colorectal Neoplasms - drug therapy; drug delivery; Drug delivery systems; Drug development; Drug Discovery - methods; Drugs; Gastrointestinal agents; Health aspects; Humans; inflammatory bowel disease; Inflammatory Bowel Diseases - drug therapy; liposome; Liposomes; Liposomes - administration & dosage; Liposomes - chemistry; Review; Transdermal medication; Vehicles; China; colorectal cancer; drug delivery; inflammatory bowel disease; liposome
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S42153

Over the past decade, liposomes became a focal point in developing drug delivery systems. New liposomes, with novel lipid molecules or conjugates, and new formulations opened possibilities for safely and efficiently treating many diseases including cancers. New types of liposomes can prolong circulation time or specifically deliver drugs to therapeutic targets. This article concentrates on current developments in liposome based drug delivery systems for treating diseases of the gastrointestinal tract. We will review different types and uses of liposomes in the development of therapeutics for gastrointestinal diseases including inflammatory bowel diseases and colorectal cancer.