Comparative Analysis of the Microbiome across the Gut-Skin Axis in Atopic Dermatitis

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 4228
• Main Authors: Park, Dong Hoon, Kim, Joo Wan, Park, Hi-Joon, Hahm, Dae-Hyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.04.2021; MDPI
• Subjects: Acne; Alzheimer's disease; Atopic dermatitis; Bacterial infections; Bioinformatics; Comparative analysis; Congenital defects; Dermatitis; Digestive system; Ecosystems; Eczema; Etiology; gut microbiome; gut–skin axis; Immune response; Immune system; Immunology; Inflammation; Integration; Intestinal microflora; Metagenomics; Microbiomes; Microbiota; Microorganisms; Psoriasis; Review; Signs and symptoms; Skin; Skin diseases; skin microbiome; Staphylococcus infections; skin microbiome; atopic dermatitis; gut microbiome; gut–skin axis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22084228

Atopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical skin symptoms and systemic immune response factors. A gut microbiome-mediated connection between emotional disorders such as depression and anxiety, and dermatologic conditions such as acne, based on the comorbidities of these two seemingly unrelated disorders, has long been hypothesized. Many aspects of this gut-brain-skin integration theory have recently been revalidated to identify treatment options for AD with the recent advances in metagenomic analysis involving powerful sequencing techniques and bioinformatics that overcome the need for isolation and cultivation of individual microbial strains from the skin or gut. Comparative analysis of microbial clusters across the gut-skin axis can provide new information regarding AD research. Herein, we provide a historical perspective on the modern investigation and clinical implications of gut-skin connections in AD in terms of the integration between the two microbial clusters.