MicroRNAs: Target Recognition and Regulatory Functions

MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and disc...

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Bibliographic Details
Published inCell Vol. 136; no. 2; pp. 215 - 233
Main Author Bartel, David P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.01.2009
Subjects
3' Untranslated Regions - metabolism
Animals
Gene Expression Regulation
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
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Summary:MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.01.002