Distant C-H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity

Activation/functionalization of inert C-H bond has undergone rapid growth in last decade and provides novel retro-synthetic disconnections for the synthesis of valuable molecules. The selectivity is often achieved by the use of directing group and is mainly limited to the proximal C-H bond. Initiall...

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Bibliographic Details
Published inCatalysis reviews. Science and engineering Vol. 57; no. 3; pp. 345 - 405
Main Authors Sharma, Ritika, Thakur, Kavita, Kumar, Rakesh, Kumar, Inder, Sharma, Upendra
Format Journal Article
LanguageEnglish
Published New York Taylor & Francis 03.07.2015
Taylor & Francis Ltd
Subjects
Activation
Bonding
C-H activation
Chemical bonds
Chemical synthesis
Communities
Directing groups
Electronics
Inert
Mechanism
Molecules
Natural products
Selectivity
Strategy
Synthesis
Transition metals
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Summary:Activation/functionalization of inert C-H bond has undergone rapid growth in last decade and provides novel retro-synthetic disconnections for the synthesis of valuable molecules. The selectivity is often achieved by the use of directing group and is mainly limited to the proximal C-H bond. Initially, meta C-H activations were based on electronic or steric control and now it can be achieved by employing nitrile-based end-on-template as the directing group. The compilation of the remote C-H activation strategy will provide the useful linkage to the scientific community. This article is focused on recent progress in remote C-H activation, mechanistic understanding, and its applications in the field of total synthesis of targeted molecules.
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ISSN:0161-4940
1520-5703
DOI:10.1080/01614940.2015.1058623