Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes

• Published in: Journal of diabetes and metabolic disorders Vol. 20; no. 1; pp. 41 - 48
• Main Authors: Ullagaddi, Mrityunjaya B., Patil, B. M., Khanal, Pukar
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2021; BioMed Central Ltd
• Subjects: Dextrose; Diabetes; Endocrinology; Glucose; Glucose metabolism; Glucose tolerance tests; Medicine; Medicine & Public Health; Metabolic Diseases; Olanzapine; Physiological aspects; Research Article; Olanzapine; Lipid metabolism; Weight gain; Locomotor activity; Zingiber officinale
• ISSN: 2251-6581; 2251-6581
• DOI: 10.1007/s40200-020-00695-x

Aim The present study aimed to investigate the effect of Zingiber officinale (ZO) extract on weight gain, food intake, locomotor activity, and lipid and glucose metabolism in olanzapine-treated rats. Methods The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile. Results Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreatic β-cell function and glucose and lipid metabolism. Conclusions ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreatic β-cell functions and lipid metabolism.