Brain-machine interface facilitated neurorehabilitation via spinal stimulation after spinal cord injury: Recent progress and future perspectives

• Published in: Brain research Vol. 1646; pp. 25 - 33
• Main Authors: Alam, Monzurul, Rodrigues, Willyam, Pham, Bau Ngoc, Thakor, Nitish V.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Animals; Brain - physiopathology; Brain-Computer Interfaces; Brain-machine interface; Electrical stimulation; Humans; Man-Machine Systems; Neurological Rehabilitation - instrumentation; Neurological Rehabilitation - methods; Neurology; Neuronal Plasticity; Paraplegia - physiopathology; Paraplegia - therapy; Prostheses and Implants; Quadriplegia - physiopathology; Quadriplegia - therapy; Recovery of Function; Signal Processing, Computer-Assisted; Spinal Cord Injuries - physiopathology; Spinal Cord Injuries - therapy; Spinal cord injury; Spinal Cord Stimulation - methods; Electrical stimulation; Spinal cord injury; Brain-machine interface
• ISSN: 0006-8993; 1872-6240; 1872-6240
• DOI: 10.1016/j.brainres.2016.05.039

Restoration of motor function is one of the highest priorities in individuals afflicted with spinal cord injury (SCI). The application of brain-machine interfaces (BMIs) to neuroprostheses provides an innovative approach to treat patients with sensorimotor impairments. A BMI decodes motor intent from cortical signals to control external devices such as a computer cursor or a robotic arm. Recent BMI systems can now use these motor intent signals to directly activate paretic muscles or to modulate the spinal cord in a way that reengage dormant neuromuscular systems below the level of injury. In this perspective, we review the progress made in the development of brain-machine-spinal-cord interfaces (BMSCIs) and highlight their potential for neurorehabilitation after SCI. The advancement and application of these neuroprostheses goes beyond improved motor control. The use of BMSCI may combine repetitive physical training along with intent-driven neuromodulation to promote neurorehabilitation by facilitating activity-dependent plasticity. Strong evidence suggests that proper timing of volitional neuromodulation facilitates long-term potentiation in the neuronal circuits that can promote permanent functional recovery in SCI subjects. However, the effectiveness of these implantable neuroprostheses must take into account the fact that there will be continuous changes in the interface between the signals of intent and the actual trigger to initiate the motor action.