Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating akt-MDM2-p53 signaling axis

• Published in: Cancer letters Vol. 380; no. 2; pp. 369 - 374
• Main Authors: Zhu, Yiping, M.D, Dai, Bo, M.D, Zhang, Hailiang, M.D, Shi, Guohai, M.D, Shen, Yijun, M.D, Ye, Dingwei, M.D
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2016; Elsevier Limited
• Subjects: Adult; Aged; AKT protein; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Bladder cancer; Cancer; Cell cycle; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholecystokinin; Dephosphorylation; DNA microarrays; Female; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomes; Hematology, Oncology and Palliative Medicine; High-Throughput Screening Assays; Humans; Infections; Kinases; Long noncoding RNA; Male; MDM2 protein; Middle Aged; Neoplasm Invasiveness; Non-coding RNA; p53; p53 Protein; Pathogenesis; Phosphorylation; Polymerase chain reaction; Proteomics - methods; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-mdm2 - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; S phase; Signal Transduction; Studies; Time Factors; Transfection; Tumor cell lines; Tumor suppressor genes; Tumor Suppressor Protein p53 - metabolism; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Wound healing; China; Long noncoding RNA; bladder cancer; p53; Bladder cancer
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.04.030

Highlights • LOC572558 levels are down-regulated in bladder cancer. • Overexpression of LOC572558 inhibited bladder cancer cell proliferation and induced cell apoptosis. • Motility changes induced by overexpression of LOC572558 • LOC572558 act as a tumor suppressor by regulating p53 pathway