The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell

• Published in: Cancer letters Vol. 364; no. 2; pp. 106 - 117
• Main Authors: Xie, Feng, Liu, Li-Bing, Shang, Wen-Qing, Chang, Kai-Kai, Meng, Yu-Han, Mei, Jie, Yu, Jia-Jun, Li, Da-Jin, Li, Ming-Qing
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.08.2015; Elsevier Limited
• Subjects: Adult; Angiogenesis; Apoptosis; Apoptosis - physiology; CCL17; Cell Communication - physiology; Cell Growth Processes - physiology; Cell Hypoxia - physiology; Cervical cancer; Cervical cancer cells; Chemokines; Cytokines; Cytokines - biosynthesis; Cytokines - immunology; Cytokines - secretion; Disease Progression; Eosinophils; Eosinophils - immunology; Eosinophils - pathology; Female; Gangrene; Gynecology; HeLa Cells; Hematology, Oncology and Palliative Medicine; Humans; Hypoxia; Medical prognosis; Middle Aged; Obstetrics; Proliferation; Recruitment; TSLP; Tumors; Uterine Cervical Neoplasms - immunology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - secretion; Womens health; Cervical cancer cells; Proliferation; TSLP; CCL17; Eosinophils
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.04.029

Highlights • Eosinophil (EOS) infiltration of the lesion site increased gradually with the progression of cervical cancer. • Hypoxia stimulated the production and release of TSLP from HeLa and SiHa cells. • TSLP stimulation led to high level of production from HeLa and SiHa cells and more EOS infiltration in cancer lesion. • TSLP promoted proliferation, up-regulated anti-inflammatory cytokines, and decreased CD80 and CD86 in HL-60 EOS. • Such educated EOS significantly promoted proliferation and restricted apoptosis in HeLa and SiHa cells.