Cortical excitability and interhemispheric inhibition after subcortical pediatric stroke: Plastic organization and effects of rTMS

• Published in: Clinical neurophysiology Vol. 121; no. 11; pp. 1922 - 1929
• Main Authors: Kirton, Adam, deVeber, Gabrielle, Gunraj, Carolyn, Chen, Robert
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ireland Ltd 01.11.2010; Elsevier
• Subjects: Adolescent; Age; Age Factors; Biological and medical sciences; Brain Ischemia - diagnosis; Brain Ischemia - physiopathology; Cerebral Cortex - physiology; Child; Cortical excitability; Developmental plasticity; Electrodiagnosis. Electric activity recording; Evoked Potentials, Motor - physiology; Female; Follow-Up Studies; Functional Laterality - physiology; Humans; Interhemispheric inhibition; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Motor Cortex - physiology; Nervous system; Neural Inhibition - physiology; Neurology; Neuronal Plasticity - physiology; Pediatric stroke; Stroke - diagnosis; Stroke - physiopathology; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods; Vascular diseases and vascular malformations of the nervous system; Young Adult; Cortical excitability; Interhemispheric inhibition; Transcranial magnetic stimulation; Developmental plasticity; Pediatric stroke; Pediatrics; Organization; Motor pathway; Central nervous system; Electrophysiology; Cardiovascular disease; Dorsal interosseous muscle; Encephalon; Vascular disease; Disability; Rest; Motor cortex; Weakness; Electromyography; Cerebrovascular disease; Human; Cerebral infarction; Nervous system diseases; Stroke; Program; Excitability; Hand; Cerebral disorder; Neurophysiology; Central nervous system disease; Brain ischemia
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2010.04.021

Abstract Objective Arterial ischemic stroke (AIS) causes disability in children but plastic developmental neurophysiology is unstudied. Imbalance of interhemispheric inhibition (IHI) in adult subcortical stroke is a therapeutic target. We hypothesized that IHI imbalance occurs in childhood AIS and is modifiable by rTMS. Methods Eligible SickKids Children’s Stroke Program patients included children >7 years with subcortical AIS (>2 years previous) and functional hand impairment. TMS with electromyography over first dorsal interosseous measured baseline motor cortex (M1) rest and 1 mV thresholds and stimulus–response curves (100–150%). Paired-pulse TMS studied bidirectional short (SIHI) and long (LIHI) interval IHI. Children were matched for age/weakness and randomized to contralesional inhibitory rTMS or sham (8 days) with measures repeated. Results Ten children (mean 13.9 years) had variable weakness (4 mild/2 moderate/4 severe). Stroke M1 motor thresholds were elevated (75 ± 25% versus 55 ± 14%, p = 0.05) and decreased with age. Baseline measures suggested excessive LIHI from non-stroke to stroke side (−46 ± 17% versus −28 ± 23%, p = 0.08). Following inhibitory rTMS, increases in stroke side maximal MEP amplitudes were suggested and LIHI from stroke to non-stroke side appeared to increase (−20% to −40%). Procedures were well tolerated. Conclusion TMS measurement of developmental plastic organization and rTMS interventions are feasible in childhood stroke and IHI imbalance may occur. Significance Improved understanding of developmental plasticity after childhood stroke will facilitate better rehabilitational therapy.