Coronary CT angiography in managing atherosclerosis

• Published in: International journal of molecular sciences Vol. 16; no. 2; pp. 3740 - 3756
• Main Authors: Eckert, Joachim, Schmidt, Marco, Magedanz, Annett, Voigtländer, Thomas, Schmermund, Axel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.02.2015; MDPI
• Subjects: atherosclerosis; Atherosclerosis - diagnostic imaging; Atherosclerosis - pathology; Atherosclerosis - physiopathology; Calcium; cardiac events; Coronary Angiography - methods; Coronary Artery Disease - diagnostic imaging; coronary calcium; coronary computed-tomography angiography (CCTA); coronary plaques; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Diagnosis, Differential; Heart; Humans; Image Processing, Computer-Assisted - methods; Medical imaging; Prognosis; Review; Tomography; Tomography, X-Ray Computed - methods
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms16023740

Invasive coronary angiography (ICA) was the only method to image coronary arteries for a long time and is still the gold-standard. Technology of noninvasive imaging by coronary computed-tomography angiography (CCTA) has experienced remarkable progress during the last two decades. It is possible to visualize atherosclerotic lesions in the vessel wall in contrast to "lumenography" performed by ICA. Coronary artery disease can be ruled out by CCTA with excellent accuracy. The degree of stenoses is, however, often overestimated which impairs specificity. Atherosclerotic lesions can be characterized as calcified, non-calcified and partially calcified. Calcified plaques are usually quantified using the Agatston-Score. Higher scores are correlated with worse cardiovascular outcome and increased risk of cardiac events. For non-calcified or partially calcified plaques different angiographic findings like positive remodelling, a large necrotic core or spotty calcification more frequently lead to myocardial infarctions. CCTA is an important tool with increasing clinical value for ruling out coronary artery disease or relevant stenoses as well as for advanced risk stratification.