Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

• Published in: Vaccine Vol. 32; no. 22; pp. 2525 - 2533
• Main Authors: Fu, Tong-Ming, An, Zhiqiang, Wang, Dai
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 07.05.2014; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Applied microbiology; Biological and medical sciences; Congenital infection and disease; Cytomegalovirus Infections - prevention & control; Cytomegalovirus Vaccines - therapeutic use; Disease Transmission, Infectious - prevention & control; Female; Fundamental and applied biological sciences. Psychology; Hearing loss; Human cytomegalovirus; Humans; Immunity, Innate; Infectious Disease Transmission, Vertical - prevention & control; Medical research; Microbiology; Miscellaneous; Neutralizing antibodies; Pregnancy; Pregnancy Complications, Infectious - therapy; Studies; T-cells; Transplants & implants; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - therapeutic use; Vaccines, Synthetic - therapeutic use; Virology; Womens health; pan DR epitope; ORF; plaque-forming unit; modified virus vaccine; individual antigen vaccine; HCMV; Venezuelan equine encephalitis virus; lymphoproliferative responses; open reading frame; MVV; human cytomegalovirus; LPR; VRP; a HCMV seronegative recipient with SOT from a seropositive donor; virus like particles; VLP; HSCT; Congenital infection and disease; T-cells; PADRE; Neutralizing antibodies; solid organ transplant; HIG; R −/D; Vaccine; dense bodies; alphavirus VEE replicon particles; TCID 50; VEE; SOT; HCMV hyperimmune globulin; infectious dose to infect 50% of tissue cells; DB; pfu; hematopoietic stem cell transplant; IAV; TCID50; Human cytomegalovirus; R−/D; Virus; Prevention; Herpesviridae; T-Lymphocyte; Betaherpesvirinae; Congenital disease; Neutralizing antibody
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.03.057

Highlight • An effective vaccine for prevention of congenital HCMV infection is of high medical significance. • Previous candidates of modified virus vaccines or individual antigen vaccines were of moderate efficacy. • A pentameric gH complex is missing in vaccine composition in all previous candidates. • This pentameric complex is the key antigen for potent neutralizing antibodies. • Implications of this complex in HCMV vaccine design are reviewed.