How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice

Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage sensing and repair is integral to survival but is largely thought to occur primarily in interphase and be repressed during mitosis due to the risk...

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Published inCells (Basel, Switzerland) Vol. 8; no. 9; p. 1049
Main Authors Thompson, Ruth, Gatenby, Rachel, Sidi, Samuel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.09.2019
MDPI
Subjects
cancer
Cell cycle
Cell fate
Chromosomes
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
Interphase
Kinases
Mitosis
Phosphorylation
Proteins
Radiation
Review
Signal transduction
Telomeres
Yeast
cancer
mitosis
DNA repair
DNA damage
cell fate
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Summary:Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage sensing and repair is integral to survival but is largely thought to occur primarily in interphase and be repressed during mitosis due to the risk of telomere fusion. There is, however, increasing evidence to suggest tight control of mitotic progression in the incidence of DNA damage, whether induced in mitotic cells or having progressed from failed interphase checkpoints. Here we will discuss what is known to date about signaling pathways controlling mitotic progression and resulting cell fate in the incidence of mitotic DNA damage.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells8091049