Traveling Bax and Forth from Mitochondria to Control Apoptosis

Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-indu...

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Bibliographic Details
Published inCell Vol. 145; no. 1; pp. 15 - 17
Main Authors Soriano, Maria Eugenia, Scorrano, Luca
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2011
Cell Press
Subjects
apoptosis
cytosol
mitochondria
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proteins
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Summary:Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-induced permeabilization of mitochondria.
Bibliography:http://dx.doi.org/10.1016/j.cell.2011.03.025
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2011.03.025