The innate immune signaling in cancer and cardiometabolic diseases: friends or foes?

• Published in: Cancer letters Vol. 387; pp. 46 - 60
• Main Authors: Wang, Weijun, Zhang, Yaxing, Yang, Ling, Li, Hongliang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.02.2017; Elsevier Limited
• Subjects: Animals; Cancer; Cardiometabolic diseases; Cardiovascular Diseases - immunology; Disease; Hematology, Oncology and Palliative Medicine; Humans; Immunity, Innate - immunology; Infections; Inflammation; Innate immune signaling; Kinases; Lectins; Liver cancer; Metabolic Diseases - immunology; Metabolism; Neoplasms - immunology; Obesity; Pancreatic cancer; Pathogenesis; Proteins; PRRs; Roles; Science; Signal Transduction; Transcription factors; Tumor necrosis factor-TNF; C-type lectin receptors; TIR domain-containing adaptor protein; MHC; RIG-I; CDK; major histocompatibility complex; IPS; azoxymethane /dextran sulfate sodium; MAPK/ERK kinase; receptor-interacting protein 2; delta like non-canonical Notch ligand; DEAD-box helicase 41; mammalian target of rapamycin complex; DUOX; nitric oxide synthase; spleen tyrosine kinase; FERM and PDZ domain-containing protein; iE-DAP; mitogen-activated protein kinase kinase kinase; BCR; Y750; TGF; innate immune signaling; LGP; B cell receptor; cyclin-dependent kinase; IRF; RLRs; dendritic cell; NAIP; HDAC; NLRX1; Interferons; TRAF family member-associated NF-κB activator-binding kinase; NF-κB-inducing kinase; NLRA; NLRC; MyD88 adaptor-like; mitogen-activated protein kinase; ASC; NALP; TAK1; NLRP; type 2 diabetes mellitus; ASK; FADD; Forkhead box protein O1; RIG-I-like receptors; TNFR-associated death domain; tyrosine 750; NAIP (neuronal apoptosis inhibitor protein), CIITA (MHC class 2 transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein); ATF; DNA-dependent protein kinase; tumor necrosis factor; TIR; DC; RIP2; stimulator of interferon genes PYHIN; glucose-6-phosphate dehydrogenase; HMGB; extracellular signal-regulated kinase; MyD88; caspase recruitment domain family member 9/B cell leukemia/lymphoma 10/ mucosa associated lymphoid tissue lymphoma translocation gene 1; PRR; Toll/IL-1 receptor; CLRs; FAS-associated protein with death domain; NOD; Syk; HCC; MAPK; ER; methionine choline deficient; laboratory of genetics and physiology; NOS; FRMPD; NLR family, pyrin domain containing; NLRs; PD-1; NADPH; DLK; melanoma differentiation-associated factor gene; pattern-recognition receptors; linear ubiquitin complex; AMP-activated protein kinase; TANK; EGFR; IFN; TGF-β-activated kinase 1; Toll-like receptors; dual oxidase; DNA-PK; STAT1; ERBIN; high-mobility group box; DCBLD2; MAP3K; xIAP; cancer; endoplasmic reticulum; TLRs; DAMP; MRE11; TRAF; HFD; interferon-stimulated gene factor; TNF; TRAM; Kirsten rat sarcoma viral oncogene; NBD; cytotoxic lymphocyte; TRAF family member-associated NF-κB activator; TRIF-related adaptor molecule; signal transducer and activator of transcription 1; endothelial growth factor receptorAPC; vascular smooth muscle cells; hepatocellular carcinoma; cAMP response element binding protein; nucleotide-binding domain; G6PD; IL; nicotinamide adenine dinucleotide phosphate; Erbb2 interacting protein; PYRIN-containing NLR; PPARγ; NLR family member X1; IRAK; retinoic acid-inducible gene I; activating transcription factor; X-linked inhibitor of apoptosis protein; programmed death 1; AMPK; Mal; VSMC; superoxide dismutase 1; ERK; T2DM; v-ral simian leukemia viral oncogene homolog B; apoptosis-associated speck-like protein containing CARD; FOXO1; CREB; danger-associated molecular patterns; CUB and LCCL domain containing 2; neuronal apoptosis inhibitor protein; IFN regulatory factor; IKK; DAI; colitis-associated cancer; MCD; absent in melanoma 2; PAMP; interferon-β promoter-stimulator; MAVS; CARD-containing NLR; apoptotic signal-regulating kinase; STING; TAB2; transforming growth factor; cellular inhibitor of apoptosis proteins; cardiometabolic diseases; AIM2-like receptors; DSS/AOM; JNK; TRADD; cIAPs; DDX41; MDA; TGF-β-activated kinase 1/MAP3K7-binding protein 2; γ-D-Glu-mDAP; LRR; IκB kinase; nucleotide-binding oligomerization domain; nuclear factor (NF)-κB essential modulator; NACHT; myeloid differentiation factor 88; TBK; c-Jun N-terminal kinase; CAC; acidic-containing NLR; ISGF; TIRAP; MEK; pathogen-associated molecular patterns; AIM2; high-fat diet; mTORC1; NEMO; peroxisome proliferator-activated receptor gamma; RalB; PRRs; double-strand break repair protein MRE11; mitochondrial antiviral signaling protein; ALRs; interleukin; IL-1 receptor-associated kinase; TNF receptor-associated factor; NOD-like receptors; leucine-rich repeat; CARD9/Bcl-10/Malt1; NIH; histone deacetylase; LUBAC; SOD1; DNA-dependent activator of interferon-regulatory factors; CTL; KRAS; Innate immune signaling; Cardiometabolic diseases; Cancer
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.06.004

Highlights • The activation of innate immune signaling by PRRs has the capacity to maintain homeostasis of human body under normal conditions. • The aberrant activation or inhibition of innate immune signaling influences the progression of cancer and cardiometabolic diseases. • Some elements of innate immune signaling are involved in these diseases partially via immune-independent manners.