Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons
Odorants cause Ca2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca2+ not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca2+-dependent adaptation, Ca2+ must...
Saved in:
| Published in | Chemical senses Vol. 34; no. 4; pp. 349 - 358 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
01.05.2009
Oxford Publishing Limited (England) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Odorants cause Ca2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca2+ not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca2+-dependent adaptation, Ca2+ must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na+/Ca2+ exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca2+ signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca2+ transient that controls signaling and adaptation in OSNs. |
|---|---|
| AbstractList | Odorants cause Ca
2+
to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca
2+
not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca
2+
-dependent adaptation, Ca
2+
must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na
+
/Ca
2+
exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca
2+
signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca
2+
transient that controls signaling and adaptation in OSNs. Odorants cause Ca2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca2+ not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca2+ -dependent adaptation, Ca2+ must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na+ /Ca2+ exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca2+ signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca2+ transient that controls signaling and adaptation in OSNs. Odorants cause Ca[sup]2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca[sup]2+ not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca[sup]2+-dependent adaptation, Ca[sup]2+ must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na[sup]+/Ca[sup]2+ exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca[sup]2+ signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca[sup]2+ transient that controls signaling and adaptation in OSNs. Odorants cause Ca(2+) to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca(2+) not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca(2+)-dependent adaptation, Ca(2+) must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na(+)/Ca(2+) exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca(2+) signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca(2+) transient that controls signaling and adaptation in OSNs. |
| Author | Weeraratne, S.D. Van Houten, Judith L. Valentine, M. Delay, R. Saidu, S. Ponissery |
| AuthorAffiliation | 1 Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA 2 Department of Neurology, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA |
| AuthorAffiliation_xml | – name: 1 Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA – name: 2 Department of Neurology, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA |
| Author_xml | – sequence: 1 givenname: S. Ponissery surname: Saidu fullname: Saidu, S. Ponissery organization: Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA – sequence: 2 givenname: S.D. surname: Weeraratne fullname: Weeraratne, S.D. organization: Department of Neurology, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA – sequence: 3 givenname: M. surname: Valentine fullname: Valentine, M. organization: Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA – sequence: 4 givenname: R. surname: Delay fullname: Delay, R. organization: Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA – sequence: 5 givenname: Judith L. surname: Van Houten fullname: Van Houten, Judith L. email: judith.vanhouten@uvm.edu organization: Department of Biology and Vermont Chemosensory Group, University of Vermont, Burlington, VT 05405, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21370447$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19304763$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0U1v1DAQBmALFdFt4cgVWUggLqH-TnJBqpaWInXbii5QwcGaOA7N4sSLnSD670mUaPm49DSS_WjsmfcA7bW-tQg9peQ1JTk_Mre2ifao2GwJyR6gBRVKJFxKvocWhKd5kilxs48OYtwQQgVn2SO0T3NORKr4An394J3FvsJXDmIDeGWbIkBr8RKcqfsGH6-vINqI63Z3tHQWBmMsroJv8KWrwHQ-3OFr28axXtg--DY-Rg8rcNE-mesh-nh6sl6eJeeX794vj88TI4XokjRToCrBiMwIUZRUgoChjJWEEiXKEkRhDM0V5QyYAFnIwkpVlKLiShaZ5IfozdR32xeNLY1tuwBOb0PdQLjTHmr9701b3-pv_qdmKqVZJoYGL-cGwf_obex0U0djnRsW4fuoByYFJ-xeOM4gOB07Pv8Pbnwf2mELmuY5Y4ySESUTMsHHGGy1-zIlegxXT-HqKdzBP_t7zj96TnMAL2YA0YCrxpDquHOM8pQIkQ7u1eR8v733zfmPdezsrx2G8H3YCk-lPrv5oj-t3l6v1eqzvuC_ASxXzUk |
| CODEN | CHSED8 |
| CitedBy_id | crossref_primary_10_1016_j_aaf_2023_05_011 crossref_primary_10_1007_s00359_012_0717_2 crossref_primary_10_1074_mcp_M113_035378 crossref_primary_10_1007_s00441_012_1483_8 crossref_primary_10_1016_j_jprot_2012_05_011 crossref_primary_10_1152_physrev_00028_2016 crossref_primary_10_1371_journal_pone_0105531 crossref_primary_10_5483_BMBRep_2012_45_11_232 crossref_primary_10_1073_pnas_1613891113 crossref_primary_10_1016_j_ijporl_2010_10_033 crossref_primary_10_1242_jeb_232074 crossref_primary_10_3389_fnagi_2016_00163 crossref_primary_10_1016_j_jphotobiol_2020_112088 crossref_primary_10_1093_chemse_bjq082 crossref_primary_10_1111_brv_12218 crossref_primary_10_1371_journal_pone_0037148 crossref_primary_10_1242_jcs_258364 crossref_primary_10_1085_jgp_200910337 |
| Cites_doi | 10.1085/jgp.112.5.529 10.1152/physrev.2001.81.1.21 10.1016/j.neures.2006.04.012 10.1038/385725a0 10.1093/chemse/bjl014 10.1074/jbc.M701129200 10.1016/j.bbrc.2004.07.156 10.1523/JNEUROSCI.17-11-04136.1997 10.1085/jgp.200308888 10.1097/00001756-199101000-00001 10.1074/jbc.273.30.18693 10.1002/cne.21290 10.1016/j.neures.2006.09.016 10.1046/j.1471-4159.2002.01221.x 10.1126/science.2255909 10.1523/JNEUROSCI.18-15-05630.1998 10.1054/ceca.2001.0212 10.1523/JNEUROSCI.2588-04.2004 10.1016/S0021-9258(19)84646-X 10.1042/BST0350919 10.1523/JNEUROSCI.12-03-00915.1992 10.1093/chemse/bjn048 10.1093/chemse/bji026 10.1021/bi00003a031 10.1152/physrev.1998.78.2.429 10.1007/s002329900323 10.1074/jbc.274.49.35227 10.1074/jbc.M104380200 10.1523/JNEUROSCI.18-12-04560.1998 10.1042/BST0350913 10.1111/j.1749-6632.2003.tb07229.x 10.1254/jphs.FP0040883 10.1085/jgp.200609626 10.1097/00001756-199409080-00013 10.1096/fasebj.8.13.7926378 10.1126/science.1063415 10.1074/jbc.M404628200 10.1021/bi00143a019 10.1093/chemse/bjg063 10.1073/pnas.220301797 10.1085/jgp.102.5.907 10.1146/annurev.physiol.64.082701.102219 10.1523/JNEUROSCI.11-11-03565.1991 10.1093/chemse/bjj017 10.1085/jgp.200609555 |
| ContentType | Journal Article |
| Copyright | The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2009 2009 INIST-CNRS The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org |
| Copyright_xml | – notice: The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2009 – notice: 2009 INIST-CNRS – notice: The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org |
| DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QP 7QR 7SS 7TK 8FD FR3 K9. P64 7X8 5PM |
| DOI | 10.1093/chemse/bjp008 |
| DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Animal Behavior Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Neurosciences Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Entomology Abstracts Technology Research Database Animal Behavior Abstracts ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | Chemoreception Abstracts Entomology Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1464-3553 |
| EndPage | 358 |
| ExternalDocumentID | 1692889571 10_1093_chemse_bjp008 19304763 21370447 10.1093/chemse/bjp008 ark_67375_HXZ_VMDST6MW_N |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIDCD NIH HHS grantid: DC 0066463 – fundername: NCRR NIH HHS grantid: P20 RR016435-06 |
| GroupedDBID | --- -E4 .2P .I3 .ZR 0R~ 18M 1TH 29B 2WC 4.4 482 48X 53G 5GY 5VS 5WA 5WD 6J9 70D A8Z AABZA AACZT AAHBH AAIMJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAVLN ABEJV ABEUO ABIVO ABIXL ABJNI ABKDP ABMNT ABNHQ ABNKS ABPTD ABQLI ABQTQ ABWST ABXVV ABZBJ ACGFO ACGFS ACIPB ACIWK ACPRK ACUFI ACUTJ ACUTO ADBBV ADEYI ADEZT ADFTL ADGKP ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEJOX AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AFXEN AGINJ AGKEF AGQXC AGSYK AHMBA AHXPO AIAGR AIJHB AJEEA AKHUL AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ARIXL ASPBG ATGXG AVWKF AXUDD AYOIW AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSCLL BSWAC BTRTY BVRKM C1A CAG CDBKE COF CS3 CZ4 DAKXR DIK DILTD D~K E3Z EBD EBS EE~ EJD EMOBN ESTFP F5P F9B FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HH5 HVGLF HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 N9A NGC NLBLG NOMLY NOYVH NU- NVLIB O0~ O9- OAWHX OBOKY OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y R44 RD5 RIG ROL ROX ROZ RUSNO RW1 RXO RZO SV3 TEORI TJX TLC TR2 W8F WH7 WOQ X7H Y6R YAYTL YKOAZ YXANX ZKX ~91 .GJ 6.Y AAPGJ AASNB AAWDT ABSAR ABSMQ ACFRR ACMRT ACPQN ACZBC AEKPW AETEA AFSHK AFYAG AGKRT AGMDO ANFBD APJGH AQDSO AQKUS ASAOO ATDFG ATTQO AVNTJ BZKNY CXTWN DFGAJ EIHJH ELUNK KC5 MBLQV MBTAY NTWIH O~Y QBD RNI RZF TCN TMA ZGI AABJS AABMN AAESY AAIYJ AANRK AAPBV ABXZS ACIMA ADEIU ADORX ADQLU AIKOY AIMBJ ALXQX ASMCH AWCFO AZQFJ BGYMP BYORX CASEJ DPORF DPPUQ IQODW OBFPC AEHUL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QP 7QR 7SS 7TK 8FD FR3 K9. P64 7X8 5PM |
| ID | FETCH-LOGICAL-c544t-786a6f4205800610f40ac122d01064dda4bcc196132a24a5b5be56bd4f365b853 |
| ISSN | 0379-864X |
| IngestDate | Tue Sep 17 21:10:39 EDT 2024 Thu Oct 24 23:02:45 EDT 2024 Fri Oct 25 09:03:43 EDT 2024 Thu Oct 10 18:01:51 EDT 2024 Thu Sep 12 18:50:43 EDT 2024 Tue Oct 15 23:36:07 EDT 2024 Sun Oct 22 16:06:33 EDT 2023 Wed Aug 28 03:24:13 EDT 2024 Wed Oct 30 09:53:04 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | mouse pumps calcium kinetics PMCA olfactory neurons Calcium Rodentia Clearance Vertebrata Mammalia Mouse Animal Plasma membrane Olfaction Perception Sensory neuron Kinetics |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c544t-786a6f4205800610f40ac122d01064dda4bcc196132a24a5b5be56bd4f365b853 |
| Notes | istex:BF256738E0BBB608ABCD091D251072E679EE8EA7 ark:/67375/HXZ-VMDST6MW-N ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/chemse/article-pdf/34/4/349/806169/bjp008.pdf |
| PMID | 19304763 |
| PQID | 199222104 |
| PQPubID | 35981 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2671884 proquest_miscellaneous_67154302 proquest_miscellaneous_20584314 proquest_journals_199222104 crossref_primary_10_1093_chemse_bjp008 pubmed_primary_19304763 pascalfrancis_primary_21370447 oup_primary_10_1093_chemse_bjp008 istex_primary_ark_67375_HXZ_VMDST6MW_N |
| PublicationCentury | 2000 |
| PublicationDate | 2009-05-01 |
| PublicationDateYYYYMMDD | 2009-05-01 |
| PublicationDate_xml | – month: 05 year: 2009 text: 2009-05-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford |
| PublicationPlace_xml | – name: Oxford – name: England |
| PublicationTitle | Chemical senses |
| PublicationTitleAlternate | Chem Senses |
| PublicationYear | 2009 |
| Publisher | Oxford University Press Oxford Publishing Limited (England) |
| Publisher_xml | – name: Oxford University Press – name: Oxford Publishing Limited (England) |
| References | 3838314 - J Biol Chem. 1985 Mar 25;260(6):3440-50 9668038 - J Biol Chem. 1998 Jul 24;273(30):18693-6 16371573 - Chem Senses. 2006 Mar;31(3):197-206 11396987 - Cell Calcium. 2001 Jul;30(1):49-57 1722719 - Neuroreport. 1991 Jan;2(1):5-8 12939394 - J Gen Physiol. 2003 Sep;122(3):349-63 11152753 - Physiol Rev. 2001 Jan;81(1):21-50 17970729 - Eur J Neurosci. 2007 Nov;26(9):2524-31 11514555 - J Biol Chem. 2001 Oct 26;276(43):39797-804 8301263 - J Gen Physiol. 1993 Nov;102(5):907-24 9562035 - Physiol Rev. 1998 Apr;78(2):429-66 18703537 - Chem Senses. 2008 Nov;33(9):839-59 1719165 - J Neurosci. 1991 Nov;11(11):3565-72 16880264 - J Gen Physiol. 2006 Aug;128(2):149-51 12763865 - Ann N Y Acad Sci. 2003 Apr;986:453-60 15576480 - FASEB J. 2005 Feb;19(2):298-300 17956245 - Biochem Soc Trans. 2007 Nov;35(Pt 5):913-8 15800218 - Chem Senses. 2005 May;30(4):317-26 16855061 - Chem Senses. 2006 Oct;31(8):725-30 16880265 - J Gen Physiol. 2006 Aug;128(2):171-84 1633161 - Biochemistry. 1992 Jul 21;31(28):6492-8 16730825 - Neurosci Res. 2006 Aug;55(4):410-20 7926378 - FASEB J. 1994 Oct;8(13):993-1002 9671654 - J Neurosci. 1998 Aug 1;18(15):5630-9 2255909 - Science. 1990 Dec 7;250(4986):1403-6 9435272 - J Membr Biol. 1998 Jan 15;161(2):163-71 1312138 - J Neurosci. 1992 Mar;12(3):915-23 11050155 - Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12869-74 9151731 - J Neurosci. 1997 Jun 1;17(11):4136-48 11826268 - Annu Rev Physiol. 2002;64:189-222 15342743 - J Neurosci. 2004 Sep 1;24(35):7754-61 15178683 - J Biol Chem. 2004 Aug 6;279(32):33742-50 15336967 - Biochem Biophys Res Commun. 2004 Oct 1;322(4):1192-203 7530047 - Biochemistry. 1995 Jan 24;34(3):965-72 9034189 - Nature. 1997 Feb 20;385(6618):725-9 17234811 - Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1516-21 17956246 - Biochem Soc Trans. 2007 Nov;35(Pt 5):919-22 9614232 - J Neurosci. 1998 Jun 15;18(12):4560-9 8393322 - Neuron. 1993 Jul;11(1):123-32 7827321 - Neuroreport. 1994 Sep 8;5(14):1741-4 11739960 - Science. 2001 Dec 7;294(5549):2176-8 17595168 - J Biol Chem. 2007 Aug 31;282(35):25640-8 10407061 - J Neurosci. 1999 Jul 15;19(14):RC19 12421373 - J Neurochem. 2002 Nov;83(4):1002-8 2530215 - J Biol Chem. 1989 Oct 25;264(30):17816-23 9806962 - J Gen Physiol. 1998 Nov;112(5):529-35 17311327 - J Comp Neurol. 2007 Apr 20;501(6):944-58 15821339 - J Pharmacol Sci. 2005 Apr;97(4):510-8 7687411 - Am J Physiol. 1993 Jun;264(6 Pt 1):C1577-86 17074407 - Neurosci Res. 2007 Jan;57(1):129-39 14627539 - Chem Senses. 2003 Oct;28(8):705-16 10575008 - J Biol Chem. 1999 Dec 3;274(49):35227-32 (21_34359490) 1985; 260 Caride (8_6381924) 1999; 274 (16_33607246) 1995; 34 Bakalyar (1_9249324) 1990; 250 (2_22424220) 2006; 128 Ronnett (43_16898452) 2002; 64 Otsuguro (36_18814744) 2005; 97 Prasad (38_18419807) 2004; 322 Jung (23_15736440) 1994; 5 Bradley (5_11436758) 2001; 294 Borisy (3_9758418) 1992; 12 Brini (6_29773612) 2007; 35 (11_19550926) 2001; 276 Pyrski (39_23681405) 2007; 501 Hallani (22_5878955) 1998; 161 Strehler (47_29773613) 2007; 35 (50_22396509) 2006; 31 Firestein (15_9623911) 1991; 11 (35_19569542) 2004; 279 Carafoli (7_15624082) 1994; 8 Lagostena (30_17914946) 2003; 28 (25_31711851) 2008; 33 Reisert (41_6222767) 1998; 112 (20_18821863) 2005; 30 Kurahashi (27_9695350) 1991; 2 Leinders-Zufall (31_6086366) 1998; 18 (51_21269713) 2006; 31 Leinders-Zufall (33_16782004) 1997; 17 (24_34636083) 1993; 11 (17_28628230) 1993; 264 Kurahashi (28_16691236) 1997; 385 (10_28942853) 2007; 282 Bozza (4_6030362) 1998; 18 (40_17783732) 2003; 122 Kozel (26_6083191) 1998; 273 SHULL (46_17640364) 2003; 986 (52_22424218) 2006; 128 SCHILD (44_5974751) 1998; 78 Restrepo (42_14578613) 1993; 102 (12_34359488) 2007; 16 (13_33742704) 1992; 31 Strotmann (49_18423769) 2004; 24 Caride (9_11185854) 2001; 30 (14_34359489) 2007; 103 Pottorf (37_17320592) 2002; 83 Gautam (19_23532894) 2007; 57 (34_19670285) 2000; 97 Strehler (48_11019943) 2001; 81 Seidler (45_5429056) 1989; 264 Gautam (18_22303230) 2006; 55 |
| References_xml | – volume: 264 start-page: C1577 issn: 0002-9513 year: 1993 ident: 17_28628230 publication-title: American Journal of Physiology -- Legacy Content – volume: 112 start-page: 529 issn: 0022-1295 issue: 5 year: 1998 ident: 41_6222767 publication-title: The Journal of General Physiology doi: 10.1085/jgp.112.5.529 contributor: fullname: Reisert – volume: 81 start-page: 21 issn: 0031-9333 issue: 1 year: 2001 ident: 48_11019943 publication-title: Physiological Reviews doi: 10.1152/physrev.2001.81.1.21 contributor: fullname: Strehler – volume: 55 start-page: 410 issn: 0168-0102 issue: 4 year: 2006 ident: 18_22303230 publication-title: Neuroscience research doi: 10.1016/j.neures.2006.04.012 contributor: fullname: Gautam – volume: 385 start-page: 725 issn: 1476-4687 issue: 6618 year: 1997 ident: 28_16691236 publication-title: Nature; Physical Science (London) doi: 10.1038/385725a0 contributor: fullname: Kurahashi – volume: 31 start-page: 725 issn: 0379-864X issue: 8 year: 2006 ident: 50_22396509 publication-title: Chemical Senses doi: 10.1093/chemse/bjl014 – volume: 282 start-page: 25640 issn: 0021-9258 issue: 35 year: 2007 ident: 10_28942853 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M701129200 – volume: 322 start-page: 1192 issn: 0006-291X issue: 4 year: 2004 ident: 38_18419807 publication-title: Biochemical and biophysical research communications doi: 10.1016/j.bbrc.2004.07.156 contributor: fullname: Prasad – volume: 17 start-page: 4136 issn: 0270-6474 issue: 11 year: 1997 ident: 33_16782004 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.17-11-04136.1997 contributor: fullname: Leinders-Zufall – volume: 122 start-page: 349 issn: 0022-1295 issue: 3 year: 2003 ident: 40_17783732 publication-title: The Journal of General Physiology doi: 10.1085/jgp.200308888 – volume: 2 start-page: 5 issn: 0959-4965 issue: 1 year: 1991 ident: 27_9695350 publication-title: Neuroreport doi: 10.1097/00001756-199101000-00001 contributor: fullname: Kurahashi – volume: 273 start-page: 18693 issn: 0021-9258 issue: 30 year: 1998 ident: 26_6083191 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.30.18693 contributor: fullname: Kozel – volume: 501 start-page: 944 issn: 0021-9967 issue: 6 year: 2007 ident: 39_23681405 publication-title: The Journal of comparative neurology doi: 10.1002/cne.21290 contributor: fullname: Pyrski – volume: 103 start-page: 1516 issn: 0027-8424 year: 2007 ident: 14_34359489 publication-title: PNAS – volume: 57 start-page: 129 issn: 0168-0102 issue: 1 year: 2007 ident: 19_23532894 publication-title: Neuroscience research doi: 10.1016/j.neures.2006.09.016 contributor: fullname: Gautam – volume: 83 start-page: 1002 issn: 0022-3042 issue: 4 year: 2002 ident: 37_17320592 publication-title: Journal of neurochemistry doi: 10.1046/j.1471-4159.2002.01221.x contributor: fullname: Pottorf – volume: 250 start-page: 1403 issn: 0036-8075 issue: 4986 year: 1990 ident: 1_9249324 publication-title: Science doi: 10.1126/science.2255909 contributor: fullname: Bakalyar – volume: 260 start-page: 440 issn: 0021-9258 year: 1985 ident: 21_34359490 publication-title: Journal of Biological Chemistry – volume: 18 start-page: 5630 issn: 0270-6474 issue: 15 year: 1998 ident: 31_6086366 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-15-05630.1998 contributor: fullname: Leinders-Zufall – volume: 30 start-page: 49 issn: 0143-4160 issue: 1 year: 2001 ident: 9_11185854 publication-title: Cell calcium doi: 10.1054/ceca.2001.0212 contributor: fullname: Caride – volume: 24 start-page: 7754 issn: 0270-6474 issue: 35 year: 2004 ident: 49_18423769 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.2588-04.2004 contributor: fullname: Strotmann – volume: 264 start-page: 17816 issn: 0021-9258 issue: 30 year: 1989 ident: 45_5429056 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)84646-X contributor: fullname: Seidler – volume: 35 start-page: 919 issn: 1470-8752 issue: Pt 5 year: 2007 ident: 47_29773613 publication-title: Biochemical Society Transactions doi: 10.1042/BST0350919 contributor: fullname: Strehler – volume: 12 start-page: 915 issn: 0270-6474 issue: 3 year: 1992 ident: 3_9758418 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.12-03-00915.1992 contributor: fullname: Borisy – volume: 33 start-page: 839 issn: 0379-864X issue: 9 year: 2008 ident: 25_31711851 publication-title: Chemical Senses doi: 10.1093/chemse/bjn048 – volume: 30 start-page: 317 issn: 0379-864X issue: 4 year: 2005 ident: 20_18821863 publication-title: Chemical Senses doi: 10.1093/chemse/bji026 – volume: 34 start-page: 965 issn: 1520-4995 year: 1995 ident: 16_33607246 doi: 10.1021/bi00003a031 – volume: 78 start-page: 429 issn: 0031-9333 issue: 2 year: 1998 ident: 44_5974751 publication-title: Physiological Reviews doi: 10.1152/physrev.1998.78.2.429 contributor: fullname: SCHILD – volume: 161 start-page: 163 issn: 0022-2631 issue: 2 year: 1998 ident: 22_5878955 publication-title: The Journal of membrane biology doi: 10.1007/s002329900323 contributor: fullname: Hallani – volume: 274 start-page: 35227 issn: 0021-9258 issue: 49 year: 1999 ident: 8_6381924 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.274.49.35227 contributor: fullname: Caride – volume: 276 start-page: 39797 issn: 0021-9258 issue: 43 year: 2001 ident: 11_19550926 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M104380200 – volume: 18 start-page: 4560 issn: 0270-6474 issue: 12 year: 1998 ident: 4_6030362 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-12-04560.1998 contributor: fullname: Bozza – volume: 35 start-page: 913 issn: 1470-8752 issue: Pt 5 year: 2007 ident: 6_29773612 publication-title: Biochemical Society Transactions doi: 10.1042/BST0350913 contributor: fullname: Brini – volume: 986 start-page: 453 issn: 0077-8923 issue: 1 year: 2003 ident: 46_17640364 publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.2003.tb07229.x contributor: fullname: SHULL – volume: 97 start-page: 510 issn: 1347-8613 issue: 4 year: 2005 ident: 36_18814744 publication-title: Journal of pharmacological sciences doi: 10.1254/jphs.FP0040883 contributor: fullname: Otsuguro – volume: 128 start-page: 149 issn: 0022-1295 issue: 2 year: 2006 ident: 52_22424218 publication-title: The Journal of General Physiology doi: 10.1085/jgp.200609626 – volume: 11 start-page: 123 issn: 1097-4199 year: 1993 ident: 24_34636083 – volume: 5 start-page: 1741 issn: 0959-4965 issue: 14 year: 1994 ident: 23_15736440 publication-title: Neuroreport doi: 10.1097/00001756-199409080-00013 contributor: fullname: Jung – volume: 8 start-page: 993 issn: 0892-6638 issue: 13 year: 1994 ident: 7_15624082 publication-title: The FASEB Journal doi: 10.1096/fasebj.8.13.7926378 contributor: fullname: Carafoli – volume: 294 start-page: 2176 issn: 0036-8075 issue: 5549 year: 2001 ident: 5_11436758 publication-title: Science doi: 10.1126/science.1063415 contributor: fullname: Bradley – volume: 279 start-page: 33742 issn: 0021-9258 issue: 32 year: 2004 ident: 35_19569542 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M404628200 – volume: 31 start-page: 6492 issn: 1520-4995 year: 1992 ident: 13_33742704 doi: 10.1021/bi00143a019 – volume: 28 start-page: 705 issn: 0379-864X issue: 8 year: 2003 ident: 30_17914946 publication-title: Chemical Senses doi: 10.1093/chemse/bjg063 contributor: fullname: Lagostena – volume: 97 start-page: 12869 issn: 0027-8424 issue: 23 year: 2000 ident: 34_19670285 publication-title: PNAS doi: 10.1073/pnas.220301797 – volume: 102 start-page: 907 issn: 0022-1295 issue: 5 year: 1993 ident: 42_14578613 publication-title: The Journal of General Physiology doi: 10.1085/jgp.102.5.907 contributor: fullname: Restrepo – volume: 64 start-page: 189 issn: 0066-4278 issue: 1 year: 2002 ident: 43_16898452 publication-title: Annual Review of Physiology doi: 10.1146/annurev.physiol.64.082701.102219 contributor: fullname: Ronnett – volume: 11 start-page: 3565 issn: 0270-6474 issue: 11 year: 1991 ident: 15_9623911 publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.11-11-03565.1991 contributor: fullname: Firestein – volume: 31 start-page: 197 issn: 0379-864X issue: 3 year: 2006 ident: 51_21269713 publication-title: Chemical Senses doi: 10.1093/chemse/bjj017 – volume: 128 start-page: 171 issn: 0022-1295 issue: 2 year: 2006 ident: 2_22424220 publication-title: The Journal of General Physiology doi: 10.1085/jgp.200609555 – volume: 16 start-page: 2524 issn: 0953-816X year: 2007 ident: 12_34359488 publication-title: The European journal of neuroscience |
| SSID | ssj0014328 |
| Score | 2.0183039 |
| Snippet | Odorants cause Ca2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body.... Odorants cause Ca(2+) to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell... Odorants cause Ca[sup]2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell... Odorants cause Ca 2+ to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell... |
| SourceID | pubmedcentral proquest crossref pubmed pascalfrancis oup istex |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 349 |
| SubjectTerms | Animals Biological and medical sciences calcium Calcium - metabolism Cell Membrane - enzymology Cells, Cultured Colforsin - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Knockout Techniques Indoles - pharmacology Kinetics Mice Mice, Inbred C57BL Mice, Knockout mouse Olfaction. Taste olfactory neurons Olfactory Receptor Neurons - drug effects Olfactory Receptor Neurons - enzymology Perception Plasma Membrane Calcium-Transporting ATPases - metabolism PMCA Protein Isoforms - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology pumps Sodium - metabolism Sodium-Calcium Exchanger - metabolism |
| Title | Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons |
| URI | https://api.istex.fr/ark:/67375/HXZ-VMDST6MW-N/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/19304763 https://www.proquest.com/docview/199222104 https://search.proquest.com/docview/20584314 https://search.proquest.com/docview/67154302 https://pubmed.ncbi.nlm.nih.gov/PMC2671884 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgewAJIdj4CINhJLQXlC21na_HqVup0NpVNB0Ve4guXyLQptXaSoy_nrOdjxYmBry0lWO5UX6X8935d3eEvIU4gyxJHTPjEJuCx5kJsmtq4nstDpAxO5G5w72-0x2JD2N73KQQqOySZXQY_7gxr-R_UMUxxFVmyf4DsvWiOIC_EV_8RITx868w_lhSAwdoAk_hXS-dou-LVmMbJnEuI-_BADcpxXithtqyTYRKE1CJJecT3XAHNQj6s_JbVesoQ3hVBYOqqMAC5zScwyHkyUpFTweoGOSxfhOeT2Vec0UeHja04guQu1xepBuB2JN0AtcNe7EKQvgN5a9KvnJ903M02fIw1bpUOMJEc4avK9sycpmvRxKU5uS6cmm5CXNdz_03_a5rX6E4T2XbyU70dW5ZXrOVVcf3_fOwMzo7C4PTcXCXbDNUQlL7vR_X9B80E1Xf3frGy_qr-AdHevkjvfiGvbItX73vVS7kgzks8OFnugPKTS7Kr0zbNdMleEQelj4HPdYC9JjcSYsdsntcwHI2vaYHVLGA1fHKDrnXrjoA7pJLKV90llEtX7SSL1oKEy3li-ZFPVTLF5XyRWv5oqV80VK-npBR5zRod82yGYcZ20IsTddzwMkEs2xPmr1WJiyIW4wlMqggkgREFMeozlucARNgR3aU2k6UiIw7doRG4VOyVcyK9DmhgC4zZGid2QDo3jOIOa7lplni-2D5lkEOqkceznXNlVBzJXiosQk1NjhRAVLPgqtvkqjo2mF3_Dm86J0MA6f3Kewb5A0idtti-xt41rNZi7uWEK5B9iqAw1IJLELJ3masZQmDvK6vIkzy2A0Bma0WoXxkaKb_YYbjoiPDLWaQZ1pcmjv15bG4ww3ibghSPUFWh9-8UuRfVJV4hqt6nnhx633tkfvNK_2SbC2vVukrtLSX0b56ZX4CSv7aCQ |
| link.rule.ids | 230,315,783,787,888,27936,27937 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+Plasma+Membrane+Calcium+ATPases+in+Calcium+Clearance+from+Olfactory+Sensory+Neurons&rft.jtitle=Chemical+senses&rft.au=Saidu%2C+SPonissery&rft.au=Weeraratne%2C+S+D&rft.au=Valentine%2C+M&rft.au=Delay%2C+R&rft.date=2009-05-01&rft.issn=0379-864X&rft.eissn=1464-3553&rft.volume=34&rft.issue=4&rft.spage=349&rft.epage=358&rft_id=info:doi/10.1093%2Fchemse%2Fbjp008&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0379-864X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0379-864X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0379-864X&client=summon |