Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats

• Published in: International journal of molecular sciences Vol. 18; no. 9; p. 1962
• Main Authors: Yamaoka, Shintaro, Oshima, Yusuke, Horiuchi, Hideki, Morino, Tadao, Hino, Masayuki, Miura, Hiromasa, Ogata, Tadanori
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.09.2017; MDPI
• Subjects: Analgesia; Analgesia - methods; Animals; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Chronic pain; Disease Models, Animal; Dorsal horn; Exercise Test; exercise therapy; Female; Gene expression; Gene Expression Regulation; Hyperalgesia; LMD; Neuralgia - genetics; Neuralgia - metabolism; Neuralgia - therapy; neuropathic pain; PACAP; Pain; Pain Management - methods; Pain perception; Pharmacology; Physical Conditioning, Animal; Pituitary adenylate cyclase-activating polypeptide; Pituitary Adenylate Cyclase-Activating Polypeptide - biosynthesis; Pituitary Adenylate Cyclase-Activating Polypeptide - genetics; Rats; RNA sequence; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNF34; Rodents; SNL model; Spinal cord; Spinal Cord - metabolism; Spinal Cord - physiopathology; Spinal Cord Dorsal Horn - metabolism; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; Spinal Nerves - surgery; Surgery; LMD; neuropathic pain; RNF34; exercise therapy; PACAP; RNA sequence; SNL model

Despite the availability of several modalities of treatment, including surgery, pharmacological agents, and nerve blocks, neuropathic pain is often unresponsive and sometimes progresses to intractable chronic pain. Although exercise therapy is a candidate for treatment of neuropathic pain, the mecha...