The Roles of Immune Cells in the Pathogenesis of Fibrosis

Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the dif...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 21; no. 15; p. 5203
Main Authors Huang, Enyu, Peng, Na, Xiao, Fan, Hu, Dajun, Wang, Xiaohui, Lu, Liwei
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.07.2020
MDPI
Subjects
adaptive immune cells
Adaptive Immunity
Animals
Apoptosis
B-Lymphocytes - immunology
Cell differentiation
Chemokines
Collagen
COVID-19
Cytokines
Cytokines - metabolism
Dendritic Cells - immunology
Disease
Fibrosis
Fibrosis - immunology
Fibrosis - pathology
Fibrosis - therapy
Humans
Immune system
Immunity, Innate
Inflammation
Inflammatory response
innate immune cells
Kidneys
Lavage
Ligands
Liver
Lymphopoiesis - immunology
Macrophages - immunology
Medical prognosis
molecular mechanism
Molecular modelling
myofibroblast
Myofibroblasts - metabolism
Neutrophils
Neutrophils - immunology
Pathogenesis
Pulmonary fibrosis
Review
Roles
Signal Transduction - immunology
T-Lymphocytes - immunology
TOR protein
adaptive immune cells
molecular mechanism
fibrosis
innate immune cells
myofibroblast
Online AccessGet full text

Cover

More Information
Summary:Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
E.H. and N.P. contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21155203