Quantitative Tissue Characterization of Infarct Core and Border Zone in Patients With Ischemic Cardiomyopathy by Magnetic Resonance Is Associated With Future Cardiovascular Events

• Published in: Journal of the American College of Cardiology Vol. 55; no. 24; pp. 2762 - 2768
• Main Authors: Heidary, Shahriar, MD, Patel, Harendra, MD, Chung, Jaehoon, MD, Yokota, Hajime, MD, Gupta, Sandeep N., PhD, Bennett, Mihoko V., PhD, Katikireddy, Chandra, MD, Nguyen, Patricia, MD, Pauly, John M., PhD, Terashima, Masahiro, MD, PhD, McConnell, Michael V., MD, Yang, Phillip C., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.06.2010; Elsevier; Elsevier Limited
• Subjects: Angina pectoris; arrhythmia; Biological and medical sciences; Cardiac Catheterization; Cardiology; Cardiology. Vascular system; Cardiomyopathies - complications; Cardiomyopathies - diagnosis; Cardiomyopathies - physiopathology; Cardiovascular; Coronary vessels; Disease Progression; Female; Follow-Up Studies; Heart; Heart attacks; Humans; Internal Medicine; ischemic cardiomyopathy; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Mortality; myocardial infarction; Myocardial Infarction - complications; Myocardial Infarction - diagnosis; Myocardial Infarction - physiopathology; Myocarditis. Cardiomyopathies; Myocardium - pathology; Prognosis; Reproducibility of Results; Stroke Volume - physiology; Ventricular Function, Left - physiology; CHF; magnetic resonance imaging; myocardial infarction; LVEF; LVESV; LV; interquartile range; left ventricular/ventricle; left ventricular ejection fraction; percutaneous coronary intervention; left ventricular end-diastolic volume; congestive heart failure; LVEDV; MI; left ventricular end-systolic volume; implantable cardioverter-defibrillator; cardiovascular events; CMR; coronary artery bypass graft; ICD; IQR; LGE; prognosis; ischemic cardiomyopathy; ICM; CVE; arrhythmia; PCI; late gadolinium enhancement; CABG; cardiac magnetic resonance; Human; Infarct; Cardiomyopathy; Magnetic resonance; Zone; Cardiovascular disease; Patient; Myocardial disease; Nuclear magnetic resonance imaging; Characterization; Tissue; Ischemia; Heart disease; Medical imagery; Circulatory system; Cardiology; Quantitative analysis
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2010.01.052

Objectives This study evaluates how characterization of tissue heterogeneity of myocardial infarction by cardiovascular magnetic resonance (CMR) is associated with cardiovascular events (CVE) in patients with ischemic cardiomyopathy (ICM). Background Prior studies demonstrated that the quantification of myocardial scar volume by CMR is superior to left ventricular end-diastolic volume, left ventricular end-systolic volume, and left ventricular ejection fraction (LVEF) in predicting future CVE in ICM patients. Evaluation of infarct heterogeneity by measuring infarct core and border zones through CMR might have a higher association with CVE. Methods Seventy patients (mean LVEF: 25 ± 11%) considered for revascularization or medical management ± implantable cardiac defibrillator were enrolled. A 1.5-T GE MRI (Signa, GE Healthcare, Milwaukee, Wisconsin) was used to acquire cine and delayed enhancement images. The patients' core and border zones of infarcted myocardium were analyzed and followed for CVE. Results Larger infarct border zone and its percentage of myocardium were found in the 29 patients (41%) who had CVE (median 13.3 g [interquartile range (IQR) 8.4 to 25.1 g] vs. 8.0 g [IQR 3.0 to 14.5 g], p = 0.02 and 7.8% [IQR 4.9% to 17.0%] vs. 4.1% [IQR 1.9% to 9.3%], p = 0.02, respectively). The core infarct zone and its percentage of myocardium, left ventricular end-diastolic volume, left ventricular end-systolic volume, and LVEF were not statistically significant. Sub-analysis of the medical management and revascularization patients with CVE demonstrated that the medically managed patients had a larger border zone, whereas there was no difference between border and core zones in the revascularization group (p < 0.05). Conclusions Quantification of core and border zones and their percentages of myocardium through CMR is associated with future CVE and might assist in the management of patients with ICM.