Immunotherapy tackles lupus

• Published in: Nature medicine Vol. 8; no. 12; pp. 1356 - 1358
• Main Author: Kammer, Gary M
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.12.2002
• Subjects: Animals; Antibodies, Monoclonal - therapeutic use; Antigens, CD; B-Lymphocytes - immunology; Immunotherapy; Interferon-gamma - physiology; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - therapy; Mice; Mice, Inbred MRL lpr; Receptors, Nerve Growth Factor - antagonists & inhibitors; Receptors, Nerve Growth Factor - immunology; Receptors, Tumor Necrosis Factor - antagonists & inhibitors; Receptors, Tumor Necrosis Factor - immunology; T-Lymphocytes - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 9

Dysregulation of T cells and B cells occurs in lupus and other autoimmune diseases. A monoclonal antibody therapy that seems to activate T cells restores some balance in a mouse model of lupus.