Immunotherapy tackles lupus

Dysregulation of T cells and B cells occurs in lupus and other autoimmune diseases. A monoclonal antibody therapy that seems to activate T cells restores some balance in a mouse model of lupus.

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Bibliographic Details
Published inNature medicine Vol. 8; no. 12; pp. 1356 - 1358
Main Author Kammer, Gary M
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.12.2002
Subjects
Animals
Antibodies, Monoclonal - therapeutic use
Antigens, CD
B-Lymphocytes - immunology
Immunotherapy
Interferon-gamma - physiology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Mice
Mice, Inbred MRL lpr
Receptors, Nerve Growth Factor - antagonists & inhibitors
Receptors, Nerve Growth Factor - immunology
Receptors, Tumor Necrosis Factor - antagonists & inhibitors
Receptors, Tumor Necrosis Factor - immunology
T-Lymphocytes - immunology
Tumor Necrosis Factor Receptor Superfamily, Member 9
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Summary:Dysregulation of T cells and B cells occurs in lupus and other autoimmune diseases. A monoclonal antibody therapy that seems to activate T cells restores some balance in a mouse model of lupus.
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ISSN:1078-8956
1546-170X
DOI:10.1038/nm1202-1356