TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis

Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the and genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between variant and variant and the risk of hepatic fibrosi...

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Published inInternational journal of molecular sciences Vol. 20; no. 6; p. 1277
Main Authors Basyte-Bacevice, Viktorija, Skieceviciene, Jurgita, Valantiene, Irena, Sumskiene, Jolanta, Petrenkiene, Vitalija, Kondrackiene, Jurate, Petrauskas, Dalius, Lammert, Frank, Kupcinskas, Juozas
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.03.2019
MDPI
Subjects
Acyltransferase
Alcohol
Bile
Biopsy
Chronic infection
Cirrhosis
Etiology
Fibrosis
Gene polymorphism
Genetic diversity
Genotype & phenotype
hepatic fibrosis
Hepatitis
Hepatitis C
Infections
Inflammation
Liver
Liver cirrhosis
Liver diseases
MBOAT7
Membrane proteins
PNPLA3
Polymorphism
Risk analysis
Risk factors
Single-nucleotide polymorphism
Studies
TM6SF2
PNPLA3
gene polymorphism
hepatic fibrosis
MBOAT7
liver cirrhosis
TM6SF2
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Summary:Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the and genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between variant and variant and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the risk variant for the development of hepatic fibrosis and liver cirrhosis. The study was conducted at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, and included 334 patients with liver cirrhosis, 128 patients with liver fibrosis, and 550 controls. SNPs were genotyped by quantitative PCR, using TaqMan allelic discrimination assays. Overall, as well as were not linked to hepatic fibrosis, alcohol or hepatitis C virus induced liver cirrhosis in an Eastern European population. These genetic variations also did not mediate the effect of SNP for liver developing liver fibrosis or liver cirrhosis.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20061277