Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 19; no. 3; p. 674
Main Authors Kim, Ju-Ryoung, Yoo, Jong Jin, Kim, Hyun Ah
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.02.2018
MDPI
Subjects
Arthritis
articular cartilage
Biocompatibility
Cartilage
Cartilage (articular)
Cartilage diseases
Inflammation
molecular pathology
Muscles
Osteoarthritis
osteoarthritis (OA)
Pain
Pathogenesis
Review
Subchondral bone
therapeutics
articular cartilage
therapeutics
osteoarthritis (OA)
molecular pathology
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Summary:Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.
Bibliography:ObjectType-Article-2
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These authors contributed equally to work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19030674