MicroRNAs in Stress Signaling and Human Disease

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role fo...

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Bibliographic Details
Published inCell Vol. 148; no. 6; pp. 1172 - 1187
Main Authors Mendell, Joshua T., Olson, Eric N.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.03.2012
Subjects
Animals
Disease - genetics
human diseases
Humans
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Signal Transduction
therapeutics
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Summary:Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.
Bibliography:http://dx.doi.org/10.1016/j.cell.2012.02.005
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.02.005