Linking biological and cognitive aging: toward improving characterizations of developmental time

• Published in: The journals of gerontology. Series B, Psychological sciences and social sciences Vol. 66 Suppl 1; no. 1; pp. i59 - 70
• Main Authors: MacDonald, Stuart W S, DeCarlo, Correne A, Dixon, Roger A
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press for Gerontological Society of America 01.07.2011
• Series: Journals of Gerontology: Series B
• Subjects: Aged; Aged, 80 and over; Aging - physiology; Aging - psychology; Biomarkers - metabolism; Blood Pressure - physiology; Body Mass Index; Cognition - physiology; Hand Strength - physiology; Humans; Longitudinal Studies; Memory, Short-Term - physiology; Mental Recall - physiology; Middle Aged; Neuropsychological Tests; Peak Expiratory Flow Rate - physiology
• ISSN: 1079-5014; 1758-5368
• DOI: 10.1093/geronb/gbr039

Chronological age is the most frequently employed predictor in life-span developmental research, despite repeated assertions that it is best conceived as a proxy for true mechanistic changes that influence cognition across time. The present investigation explores the potential that selected functional biomarkers may contribute to the more effective conceptual and operational definitions of developmental time. We used data from the Victoria Longitudinal Study to explore both static and dynamic biological or physiological markers that arguably influence process-specific mechanisms underlying cognitive changes in late life. Multilevel models were fit to test the dynamic coupling between change in theoretically relevant biomarkers (e.g., grip strength, pulmonary function) and change in select cognitive measures (e.g., executive function, episodic and semantic memory). Results showed that, independent of the passage of developmental time (indexed as years in study), significant time-varying covariation was observed linking corresponding declines for select cognitive outcomes and biological markers. Our findings support the interpretation that cognitive decline is not due to chronological aging per se but rather reflects multiple causal factors from a broad range of biological and physical health domains that operate along the age continuum.