Applying decision tree for identification of a low risk population for type 2 diabetes. Tehran Lipid and Glucose Study

• Published in: Diabetes research and clinical practice Vol. 105; no. 3; pp. 391 - 398
• Main Authors: Ramezankhani, Azra, Pournik, Omid, Shahrabi, Jamal, Khalili, Davood, Azizi, Fereidoun, Hadaegh, Farzad
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.2014
• Subjects: Adult; Aged; Arterial Pressure; Blood Glucose - analysis; Body Mass Index; Body Weights and Measures; Computational Biology; Data Mining; Decision Support Techniques; Decision tree; Decision Trees; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Educational Status; Employment; Endocrinology & Metabolism; Female; Humans; Incidence; Iran - epidemiology; Longitudinal Studies; Male; Marital Status; Middle Aged; Prediction model; Risk Factors; Sensitivity and Specificity; Smoking; Triglycerides - blood; Type 2 diabetes; Iran; Type 2 diabetes; Decision tree; Prediction model
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2014.07.003

The aim of this study was to create a prediction model using data mining approach to identify low risk individuals for incidence of type 2 diabetes, using the Tehran Lipid and Glucose Study (TLGS) database. For a 6647 population without diabetes, aged ≥20 years, followed for 12 years, a prediction model was developed using classification by the decision tree technique. Seven hundred and twenty-nine (11%) diabetes cases occurred during the follow-up. Predictor variables were selected from demographic characteristics, smoking status, medical and drug history and laboratory measures. We developed the predictive models by decision tree using 60 input variables and one output variable. The overall classification accuracy was 90.5%, with 31.1% sensitivity, 97.9% specificity; and for the subjects without diabetes, precision and f-measure were 92% and 0.95, respectively. The identified variables included fasting plasma glucose, body mass index, triglycerides, mean arterial blood pressure, family history of diabetes, educational level and job status. In conclusion, decision tree analysis, using routine demographic, clinical, anthropometric and laboratory measurements, created a simple tool to predict individuals at low risk for type 2 diabetes.